{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:15:43Z","timestamp":1783577743571,"version":"3.55.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The proliferation of internet-based technologies has enabled the development of supportive intervention that have proven efficacious in several health education fields. However, their specific utility for primiparas has yet to be systematically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 332 primiparas were enrolled between January 2021 and December 2023 to participate in a randomized controlled trial, and were equally assigned to two groups (166 per group). The control group received conventional health education, while the intervention group received an internet-based supportive intervention. After excluding dropouts, 141 participants in the intervention group and 137 in the control group were included for per-protocol analysis. Maternal and neonatal health knowledge, pregnancy stress, and fear of childbirth (FOC) were evaluated using the Maternal and Infant Knowledge Scale, Pregnancy Stress Rating Scale (PSRS), and Childbirth Fear Questionnaire (CAQ), respectively. Maternal and neonatal clinical outcomes were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After the intervention, the intervention group demonstrated significantly higher knowledge scores in nine out of ten domains, with a higher post-intervention total score (78.45 \u00b1 5.97 vs. 67.31 \u00b1 7.04,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Similarly, the intervention group reported significantly lower pregnancy stress across all four domains, with a lower post-intervention total score (31.67 \u00b1 6.85 vs. 38.92 \u00b1 8.76,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). FOC was also significantly lower in the intervention group across three dimensions, with a lower post-intervention total score (23.56 \u00b1 4.73 vs. 28.24 \u00b1 5.81,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Furthermore, sensitivity analyses under the intention-to-treat (ITT) principle showed that these findings were robust to missing data, confirming the benefits of the intervention group. The intervention group had a significantly higher rate of spontaneous vaginal delivery and lower incidences of gestational diabetes, macrosomia, low birth weight, as well as lower overall incidences of adverse maternal and neonatal events (21.28% vs. 35.04%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011; 19.86% vs. 34.31%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007, respectively). However, sensitivity analyses showed that adverse events were not robust to missing data, and therefore these results should be interpreted with caution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The internet-based supportive intervention is associated with higher knowledge, lower stress and FOC, and potential maternal and neonatal benefits among primiparas, suggesting its value as an antenatal education strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1795397","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:34:43Z","timestamp":1783575283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of internet-based supportive intervention on knowledge, pregnancy stress, fear of childbirth, and pregnancy outcomes in primiparas"],"prefix":"10.3389","volume":"13","author":[{"given":"Fangqin","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Maternal and Child Health Hospital of Linping District, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal and Child Health Hospital of Linping District, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal and Child Health Hospital of Linping District, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal and Child Health Hospital of Linping District, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0328819","DOI":"10.1371\/journal.pone.0328819","article-title":"Childbirth fear and its associated factors among pregnant women attending antenatal care at gondar city public health institutions, Northwest Ethiopia, 2022.","volume":"20","author":"Temesgan","year":"2025","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"104511","DOI":"10.1016\/j.midw.2025.104511","article-title":"Factors associated with breastfeeding knowledge and attitudes among non-pregnant, nulliparous women of reproductive age: scoping review.","volume":"148","author":"Malekian","year":"2025","journal-title":"Midwifery"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10055","DOI":"10.1080\/14767058.2022.2089550","article-title":"Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study.","volume":"35","author":"Nijsten","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1080\/07399332.2021.1935959","article-title":"The effect of antenatal education on expectant mother\u2019s childbirth attitudes, maternal role attainment, and self-confidence levels.","volume":"44","author":"Kaka\u015f\u00e7\u0131","year":"2023","journal-title":"Health Care Women Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s10995-025-04048-z","article-title":"What do antenatal women want from their antenatal education?","volume":"29","author":"Larkai","year":"2025","journal-title":"Matern Child Health J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/ajo.13743","article-title":"Evaluation of an online education program for healthcare professionals on best practice management of perinatal deaths: improve E learning.","volume":"64","author":"Medeiros","year":"2024","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1186963","DOI":"10.3389\/fpubh.2023.1186963","article-title":"The healthy moms and babies app to prevent postpartum depression: analysis of user-profiles and dropout cases.","volume":"11","author":"Rodriguez-Mu\u00f1oz","year":"2023","journal-title":"Front Public Health"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e67386","DOI":"10.2196\/67386","article-title":"Internet-based cognitive behavioral therapy for preventing postpartum depressive symptoms among pregnant individuals with depression: multicenter randomized controlled trial in China.","volume":"27","author":"Duan","year":"2025","journal-title":"J Med Internet Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/ijgo.14792","article-title":"Effectiveness of mhealth-based educational interventions to improve self-care during pregnancy: a pragmatic randomized controlled trial from Northern India.","volume":"163","author":"Persis","year":"2023","journal-title":"Int J Gynaecol Obstet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1111\/jocn.16399","article-title":"Effectiveness of Internet-based psychological interventions for treating perinatal depression: a systematic review and meta-analysis.","volume":"32","author":"Li","year":"2023","journal-title":"J Clin Nurs"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e66073","DOI":"10.2196\/66073","article-title":"An internet-based and mobile family management intervention for mothers of very preterm infants hospitalized in the neonatal intensive care unit (the preemie progress program): pilot randomized controlled trial.","volume":"9","author":"Weber","year":"2025","journal-title":"JMIR Form Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0280622","DOI":"10.1371\/journal.pone.0280622","article-title":"Effect of a social media-based health education program on postnatal care (PNC) knowledge among pregnant women using smartphones in Dhulikhel hospital: a randomized controlled trial.","volume":"18","author":"Chaudhary","year":"2023","journal-title":"PLoS One"},{"key":"B13","volume-title":"National Basic Public Health Service Specification (Third Edition) [Internet].","year":"2017"},{"key":"B14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3761\/j.issn.1672-9234.2021.09.018","article-title":"Construction of\u201cinternet+\u201dcentering pregnancy health care course in late pregnancy.","volume":"18","author":"Hu","year":"2021","journal-title":"Chin J Nurs Educ."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.62347\/UMKH2239","article-title":"Effects of internet-based integrated care on breastfeeding outcomes and emotional well-being in primiparous women.","volume":"16","author":"Shi","year":"2024","journal-title":"Am J Transl Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3969\/j.issn.1673-5625.2017.05.015","article-title":"Development and evaluation of maternal and child health literacy scale.","volume":"34","author":"Xu","year":"2017","journal-title":"Chin J Soc Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/jnr.0000000000000047","article-title":"Revision and validation of a scale to assess pregnancy stress.","volume":"23","author":"Chen","year":"2015","journal-title":"J Nurs Res"},{"key":"B18","first-page":"132","article-title":"Development of maternal and infant health literacy scale and its reliability and validity analysis.","volume":"40","author":"Jiang","year":"2024","journal-title":"Chin J Health Educ."},{"key":"B19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3870\/j.issn.1001-4152.2016.02.081","article-title":"Reliability and validity of the Chinese version of childbirth attitudes questionnaire.","volume":"31","author":"Wei","year":"2016","journal-title":"J Nurs Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4040825","DOI":"10.1155\/2024\/4040825","article-title":"Navigating pregnancy: information sources and lifestyle behavior choices-a narrative review.","volume":"2024","author":"Gjestvang","year":"2024","journal-title":"J Pregnancy"},{"key":"B21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/0272684X221095659","article-title":"Maternal health literacy, health information-seeking behavior and pregnancy outcomes among iranian pregnant women: a cross-sectional study.","volume":"44","author":"Sabetghadam","year":"2023","journal-title":"Community Health Equity Res Policy"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e20250188","DOI":"10.1590\/1980-220X-REEUSP-2025-0188en","article-title":"Educational technologies on signs of gestational risk and\/or labor for pregnant women: a scoping review.","volume":"59","author":"Silva","year":"2025","journal-title":"Rev Esc Enferm USP"},{"key":"B23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.22442\/jlumhs.2025.01206","article-title":"The effect of using the ebumil android application on knowledge and independence of pregnant women about pregnancy care.","volume":"24","author":"Kartini","year":"2025","journal-title":"J Liaq Uni Med Health Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1186\/s40359-025-03237-3","article-title":"Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants.","volume":"13","author":"Meng","year":"2025","journal-title":"BMC Psychol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/jocn.16338","article-title":"A longitudinal study of perinatal depression and the risk role of cognitive fusion and perceived stress on postpartum depression.","volume":"32","author":"Liu","year":"2023","journal-title":"J Clin Nurs"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0278432","DOI":"10.1371\/journal.pone.0278432","article-title":"Effects of relaxation interventions during pregnancy on maternal mental health, and pregnancy and newborn outcomes: a systematic review and meta-analysis.","volume":"19","author":"Abera","year":"2024","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1186\/s12884-023-05890-1","article-title":"Predictors of pregnancy stress and psychological birth trauma in women undergoing vaginal delivery: a cross-sectional study in China.","volume":"23","author":"Ma","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0320616","DOI":"10.1371\/journal.pone.0320616","article-title":"Design and determination of the psychometric properties of a fear of childbirth tool for Iranian adolescent mothers: an exploratory sequential mixed method study protocol.","volume":"20","author":"Hoseini","year":"2025","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/02646838.2021.1995598","article-title":"Prevalence and associated factors of fear for childbirth among pregnant women in eastern Sudan.","volume":"41","author":"Mandar","year":"2023","journal-title":"J Reprod Infant Psychol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12978-024-01902-1","article-title":"The psychometric properties of fear of childbirth instruments: a systematic review.","volume":"21","author":"Hoseini","year":"2024","journal-title":"Reprod Health"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0293815","DOI":"10.1371\/journal.pone.0293815","article-title":"The effect of an mHealth application based on continuous support and education on fear of childbirth, self-efficacy, and birth mode in primiparous women: a randomized controlled trial.","volume":"18","author":"Khademioore","year":"2023","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e64508","DOI":"10.7759\/cureus.64508","article-title":"Influence of antenatal education on birth outcomes: a systematic review focusing on primiparous women.","volume":"16","author":"Athinaidou","year":"2024","journal-title":"Cureus"},{"key":"B33","first-page":"163","article-title":"Effect of all-media health education on self-confidence and subjective well-being on breastfeeding among primiparas.","volume":"36","author":"Zhang","year":"2020","journal-title":"Chin J Health Educ."},{"key":"B34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.18332\/ejm\/200747","article-title":"The role of antenatal education on maternal self-efficacy, fear of childbirth, and birth outcomes: a systematic review and meta-analysis.","volume":"9","author":"Zaman","year":"2025","journal-title":"Eur J Midwifery"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.3390\/nu17213400","article-title":"Prediction of gestational diabetes mellitus: a nomogram model incorporating lifestyle, nutrition and health literacy factors.","volume":"17","author":"Fu","year":"2025","journal-title":"Nutrients"},{"key":"B36","first-page":"63","article-title":"The influence of maternal nutrition on fetal development and birth outcomes.","volume":"200","author":"Danley","year":"2025","journal-title":"World Sci News."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e0331913","DOI":"10.1371\/journal.pone.0331913","article-title":"Effects of digital health counseling and behavioral interventions on weight management during pregnancy and postpartum: a systematic review and meta-analysis of randomized controlled trials.","volume":"20","author":"Khademioore","year":"2025","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1186\/s12884-025-07955-9","article-title":"Impact of web-based breastfeeding education on breastfeeding self-efficacy and exclusive breastfeeding rates among primiparous mothers in iran: a quasi-experimental study.","volume":"25","author":"Fallah-Karimi","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"key":"B39","doi-asserted-by":"publisher","first-page":"101635","DOI":"10.1016\/j.wombi.2024.101635","article-title":"Evaluating a woman-centred web-based breastfeeding educational intervention in Saudi Arabia: a before-and-after quasi-experimental study.","volume":"37","author":"Alahmed","year":"2024","journal-title":"Women Birth"},{"key":"B40","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/jpepsy\/jsad086","article-title":"Online intervention targeting postnatal depression and anxiety in Chilean first-time mothers: feasibility trial.","volume":"49","author":"Coo","year":"2024","journal-title":"J Pediatr Psychol"},{"key":"B41","first-page":"A12220775","article-title":"First-time mothers\u2019 experiences with a web-intervention on maternal mentalisation and mental health.","volume":"70","author":"Lorenzen","year":"2023","journal-title":"Dan Med J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12911-026-03406-3","article-title":"Applying a multi-level usability framework for evaluation of a pregnancy health.","volume":"26","author":"Asadollahi","year":"2026","journal-title":"BMC Med Inform Decis Mak"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1017\/S0021932021000535","article-title":"Childbearing culture: a prominent context in the process of maternal role attainment in Iranian mothers with preterm neonates.","volume":"54","author":"Naeini","year":"2022","journal-title":"J Biosoc Sci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12978-021-01196-7","article-title":"Recommendations for improving primiparous women\u2019s childbirth experience: results from a multiphase study in Iran.","volume":"18","author":"Homaie","year":"2021","journal-title":"Reprod Health."},{"key":"B45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12884-025-07244-5","article-title":"Barriers and facilitators for mHealth utilization in pregnancy care: a qualitative analysis of pregnant women and stakeholder\u2019s perspectives.","volume":"25","author":"Asadollahi","year":"2025","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1795397\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:34:46Z","timestamp":1783575286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1795397\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":45,"alternative-id":["10.3389\/fmed.2026.1795397"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1795397","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"article-number":"1795397"}}