{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:09:21Z","timestamp":1779426561425,"version":"3.53.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Penetrating ocular trauma is the main cause of irreversible loss of unilateral vision in young men. Among its rare presentations, accidental intravitreal injection of non-human biological agents poses unique diagnostic and therapeutic challenges. The bivalent inactivated vaccine against swine foot-and-mouth disease (FMD) serotype O and A is currently an effective means of preventing swine FMD virus infection and is strictly prohibited for human use. To date, no clinical reports have been observed regarding intraocular exposure (particularly injection into the vitreous cavity) of this vaccine. This article presents a case of severe noninfectious intraocular inflammation resulting from accidental injection of the bivalent inactivated vaccine against swine FMD serotype O and A into the vitreous cavity, aiming to analyze its unique pathogenesis and summarize diagnostic and therapeutic lessons.<\/jats:p>","DOI":"10.3389\/fmed.2026.1796518","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:48:47Z","timestamp":1779425327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Accidental intravitreal injection of a veterinary inactivated FMD vaccine resulting in noninfectious intraocular inflammation: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Hebei Key Laboratory of Ophthalmology, Hebei Eye Hospital, Hebei Ophthalmology Research Institute","place":["Xingtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Jia","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Ophthalmology, Hebei Eye Hospital, Hebei Ophthalmology Research Institute","place":["Xingtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Ophthalmology, Hebei Eye Hospital, Hebei Ophthalmology Research Institute","place":["Xingtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Cao","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Ophthalmology, Hebei Eye Hospital, Hebei Ophthalmology Research Institute","place":["Xingtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Ophthalmology, Hebei Eye Hospital, Hebei 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