{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:38:46Z","timestamp":1792172326946,"version":"4.4.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a systemic inflammatory disease frequently comorbid with obesity, as both conditions share common pathogenic pathways. Acupoint catgut embedding (ACE), a sustained-release form of acupuncture, has demonstrated potential in modulating both immune and metabolic responses. This trial aims to evaluate the efficacy, safety, and underlying mechanisms of ACE in patients with mild psoriasis and concurrent overweight\/obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a multicenter, randomized, double-blind, sham-controlled trial. Participants aged \u2265 18\u202fyears with mild plaque psoriasis (PASI&amp;lt; 3, BSA\u202f&amp;lt;\u202f3%) and overweight (BMI\u202f\u2265\u202f24\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) will be randomized (1:1) to receive either verum ACE at 14 specific acupoints or a sham procedure. Interventions will be administered every 2\u202fweeks for 8\u202fweeks. The primary endpoints are the changes in PASI score and BMI from baseline to week 8. Secondary outcomes include the Dermatology Life Quality Index (DLQI), waist circumference (WC), lipid profiles, and systemic inflammatory markers. The safety of the procedure will be monitored through the recording of adverse events and conducting laboratory tests. Participants will be followed through week 32 to evaluate long-term therapeutic durability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This trial will provide high-quality evidence regarding the \u201cdual-action\u201d potential of ACE in simultaneously improving psoriatic lesions and metabolic dysfunction, establishing its role as an integrative therapy for this specific patient phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/itmctr.ccebtcm.org.cn\/<\/jats:ext-link>\n                      , identifier ITMCTR2025002460.\n                    <\/jats:p>\n                  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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, 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