{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:06:37Z","timestamp":1774364797183,"version":"3.50.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute superior mesenteric artery embolism (ASMAE) is a clinically rare acute abdominal condition and a type of acute mesenteric ischemia. It is characterized by sudden onset, rapid progression, and a high rate of misdiagnosis. Due to atypical early symptoms (such as dissociation between abdominal pain and physical signs), diagnosis and treatment are often delayed. Currently, there is no highly specific biomarker available for definitive diagnosis. Treatment typically involves anticoagulation and vasospasmolysis, with interventional or surgical intervention selected based on the extent of intestinal wall necrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>For a 42-year-old male patient with superior mesenteric artery embolism complicated by intestinal necrosis, continuous monitoring was carried out through interventional therapy, pharmacological support, and surgical treatment, along with abdominal CTA, arteriography, CT scans, and clinical examinations. Follow-up and timely re-examinations were conducted after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient was successfully treated with a sequential therapeutic approach combining \u201cinterventional thrombectomy\/thrombolysis\u201d and \u201csurgical bowel resection.\u201d Interventional treatment partially recanalized the occluded vessel but failed to completely prevent intestinal necrosis. Timely surgical intervention removed 10 cm of necrotic small intestine, preventing further deterioration of the condition. Postoperative vascular imaging showed significant improvement in superior mesenteric artery blood flow. The patient eventually recovered and was discharged, with recent follow-up showing no discomfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinical manifestations and signs of this case of superior mesenteric artery embolism were atypical, and no abnormalities were found in D-dimer and lactate upon admission. However, when intestinal necrosis occurs, the early laboratory findings and signs become more typical. Through timely CT and CTA imaging assessments, dynamic monitoring of the condition, and multidisciplinary intervention, successful treatment was achieved, providing valuable insights for the diagnosis and management of similar cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1796951","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:26:31Z","timestamp":1774023991000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined endovascular and surgical management of acute superior mesenteric artery embolism complicated by intestinal necrosis: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Yanyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Andrology, Seventh People\u2019s Hospital affiliated to Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]},{"name":"Department of Gastroenterology, Affiliated Nanjing Jiangbei Hospital of Nantong University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Nanjing Jiangbei Hospital of Nantong University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Nanjing Jiangbei Hospital of Nantong University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoming","family":"Yan","sequence":"additional","affiliation":[{"name":"Interventional Department, Affiliated Nanjing Jiangbei Hospital of Nantong University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Nanjing Jiangbei Hospital of Nantong University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Affiliated Nanjing Jiangbei Hospital of Nantong University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Medical School of Nantong University","place":["Nantong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Andrology, Seventh People\u2019s Hospital affiliated to Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1177\/08465371221094280","article-title":"An update on acute mesenteric ischemia.","volume":"74","author":"Yu","year":"2023","journal-title":"Can Assoc Radiol J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e250012","DOI":"10.1148\/rg.250012","article-title":"Acute mesenteric ischemia: pathophysiology-based approach to imaging findings and diagnosis.","volume":"45","author":"Lee","year":"2025","journal-title":"Radiographics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1093\/bjs\/znad021","article-title":"Acute mesenteric ischaemia.","volume":"110","author":"Fuglseth","year":"2023","journal-title":"Br J Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10445","DOI":"10.1007\/s00210-025-03914-5","article-title":"Identification and potential mechanism of a novel gastric cancer suppressor tRF-24-6VR8K09LE9.","volume":"398","author":"Tang","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1177\/17085381221085150","article-title":"Percutaneous mechanical thrombectomy in the management of early acute superior mesenteric artery embolism.","volume":"31","author":"Yu","year":"2023","journal-title":"Vascular."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1016\/j.asjsur.2022.05.076","article-title":"A case of acute superior mesenteric artery embolism caused by constipation after hemorrhoid surgery.","volume":"45","author":"Du","year":"2022","journal-title":"Asian J Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13244-025-01986-8","article-title":"Acute arterial mesenteric ischaemia: comparison of partial and complete occlusion of the superior mesenteric artery.","volume":"16","author":"Dufay","year":"2025","journal-title":"Insights Imaging."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/j.jvir.2025.08.020","article-title":"Mechanical thrombectomy using a balloon guide catheter for acute occlusion of the superior mesenteric artery.","volume":"36","author":"Yamasaki","year":"2025","journal-title":"J Vasc Interv Radiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1403218","DOI":"10.3389\/fmed.2024.1403218","article-title":"Purse-string suture with nylon cords and metal clips for the treatment of duodenal fistulae under the endoscope: a case report.","volume":"11","author":"Wang","year":"2024","journal-title":"Front Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.17235\/reed.2023.10074\/2023","article-title":"Traumatic intestinal ischemic necrosis.","volume":"117","author":"Han","year":"2025","journal-title":"Rev Esp Enferm Dig."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/s41467-024-45539-x","article-title":"EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.","volume":"15","author":"Wu","year":"2024","journal-title":"Nat Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e2706","DOI":"10.1128\/mBio.02706-20","article-title":"Fusobacterium nucleatum secretes outer membrane vesicles and promotes intestinal inflammation.","volume":"12","author":"Engevik","year":"2021","journal-title":"mBio."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/15266028241300927","article-title":"Acute superior mesenteric artery embolism with infective endocarditis: is there a role for endovascular treatment?","author":"Zhou","year":"2024","journal-title":"J Endovasc Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e14446","DOI":"10.1097\/MD.0000000000014446","article-title":"Review: acute superior mesenteric artery embolism: a vascular emergency cannot be ignored by physicians.","volume":"98","author":"Liao","year":"2019","journal-title":"Medicine."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3892\/etm.2024.12755","article-title":"Acute superior mesenteric artery embolism: a case report.","volume":"29","author":"Wang","year":"2025","journal-title":"Exp Ther Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jss.2016.12.023","article-title":"Attenuation of intestinal ischemia-reperfusion-injury by \u03b2-alanine: a potentially glycine-receptor mediated effect.","volume":"211","author":"Brencher","year":"2017","journal-title":"J Surg Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1329636","DOI":"10.3389\/fphar.2024.1329636","article-title":"GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs.","volume":"15","author":"Ji","year":"2024","journal-title":"Front Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1137145","DOI":"10.3389\/fbioe.2023.1137145","article-title":"Research progress on albumin-based hydrogels: properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering.","volume":"11","author":"Meng","year":"2023","journal-title":"Front Bioeng Biotechnol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e2220173120","DOI":"10.1073\/pnas.2220173120","article-title":"Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice.","volume":"120","author":"Meng","year":"2023","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1517887","DOI":"10.3389\/fphar.2025.1517887","article-title":"TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response.","volume":"16","author":"Qi","year":"2025","journal-title":"Front Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/13543776.2025.2462849","article-title":"Small molecules targeting immune checkpoint proteins for cancer immunotherapy: a patent and literature review (2020-2024).","volume":"35","author":"Geng","year":"2025","journal-title":"Expert Opin Ther Pat."},{"key":"B22","doi-asserted-by":"publisher","first-page":"117370","DOI":"10.1016\/j.bcp.2025.117370","article-title":"From orphan receptor to inflammation regulation: the role of GPR35 in the pathogenesis of depression.","volume":"242","author":"Yang","year":"2025","journal-title":"Biochem Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1080\/00365510701646264","article-title":"Diagnostic accuracy of plasma biomarkers for intestinal ischaemia.","volume":"68","author":"Block","year":"2008","journal-title":"Scand J Clin Lab Invest."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1111\/acem.12254","article-title":"The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis.","volume":"20","author":"Cudnik","year":"2013","journal-title":"Acad Emerg Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.1111\/jocs.17001","article-title":"Cardiac gated multidetector computed tomography (MDCT) to determine valvular leaflet thrombosis and leaflet restriction.","volume":"37","author":"Levy","year":"2022","journal-title":"J Card Surg."},{"key":"B26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10787-019-00683-5","article-title":"Human umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease by inhibiting ERK phosphorylation in neutrophils.","volume":"28","author":"Wang","year":"2020","journal-title":"Inflammopharmacology."},{"key":"B27","doi-asserted-by":"publisher","first-page":"108176","DOI":"10.1016\/j.pharmthera.2022.108176","article-title":"Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy.","volume":"238","author":"Pan","year":"2022","journal-title":"Pharmacol Ther."},{"key":"B28","doi-asserted-by":"publisher","first-page":"109066","DOI":"10.1016\/j.intimp.2022.109066","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells regulate lymphangiogenesis via the miR-302d-3p\/VEGFR3\/AKT axis to ameliorate inflammatory bowel disease.","volume":"110","author":"Zhang","year":"2022","journal-title":"Int Immunopharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/ph17050607","article-title":"Therapeutic prospects of mesenchymal stem cell and their derived exosomes in the regulation of the gut microbiota in inflammatory bowel disease.","volume":"17","author":"Qiao","year":"2024","journal-title":"Pharmaceuticals."},{"key":"B30","doi-asserted-by":"publisher","first-page":"21825","DOI":"10.1038\/s41598-025-06717-z","article-title":"An ovalbumin-based hydrogel loaded with dendrobium polysaccharide for promoting wound healing while reducing inflammations.","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"111271","DOI":"10.1016\/j.mehy.2024.111271","article-title":"Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: a hypothesis.","volume":"184","author":"Meng","year":"2024","journal-title":"Medical Hypotheses."},{"key":"B32","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jvs.2013.06.084","article-title":"Comparison of open and endovascular treatment of acute mesenteric ischemia.","volume":"59","author":"Beaulieu","year":"2014","journal-title":"J Vasc Surg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/ajg.2017.38","article-title":"Predictive factors of intestinal necrosis in acute mesenteric ischemia: prospective study from an intestinal stroke center.","volume":"112","author":"Nuzzo","year":"2017","journal-title":"Am J Gastroenterol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1007\/s00330-022-09258-5","article-title":"Radiological predictive factors of transmural intestinal necrosis in acute mesenteric ischemia: systematic review and meta-analysis.","volume":"33","author":"Zeng","year":"2023","journal-title":"Eur Radiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.suc.2023.04.017","article-title":"Current approaches for mesenteric ischemia and visceral aneurysms.","volume":"103","author":"Scallan","year":"2023","journal-title":"Surg Clin North Am."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1167901","DOI":"10.3389\/fradi.2023.1167901","article-title":"Case report: ultrasound assisted catheter directed thrombolysis of an embolic partial occlusion of the superior mesenteric artery.","volume":"3","author":"Bongiovanni","year":"2023","journal-title":"Front Radiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12872-023-03066-5","article-title":"Superior mesenteric artery embolism after radiofrequency ablation in regularly anticoagulated patients with paroxysmal atrial fibrillation: a case report.","volume":"23","author":"Jing","year":"2023","journal-title":"BMC Cardiovasc Disord."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1796951\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:23:07Z","timestamp":1774362187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1796951\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":37,"alternative-id":["10.3389\/fmed.2026.1796951"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1796951","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"article-number":"1796951"}}