{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:52:41Z","timestamp":1781679161022,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the predictive value of contrast-enhanced ultrasonography (CEUS) in differentiating cervical tuberculous lymphadenitis (CTL) from non-tuberculous cervical lymphadenitis (NCTL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 303 patients with cervical lymphadenopathy. Various CEUS features, including the long axis diameter (L), short axis diameter (S), length-to-width ratio (L\/S), presence of the hilum, boundary clarity, internal echogenicity, calcification, necrosis, blood flow distribution within the lymph node, and direction of blood flow, were examined. A multivariate logistic regression model was developed to predict CTL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The model identified key predictive factors, including absent hilum, necrosis, heterogeneous enhancement, perfusion defects, peripheral ring enhancement, and non-centrifugal enhancement. In the training cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 202), the model achieved an AUC of 0.913, with high specificity (77.5%) and sensitivity (92.6%). Similar performance was observed in the validation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 101, AUC = 0.917).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CEUS analysis demonstrates significant efficacy in distinguishing CTL from NCTL, thereby enhancing diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1797878","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:57:39Z","timestamp":1781675859000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of conventional and contrast-enhanced ultrasound in diagnosing cervical tuberculous lymphadenitis"],"prefix":"10.3389","volume":"13","author":[{"given":"Jun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, Hangzhou Red Cross Hospital, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Hangzhou Red Cross Hospital, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Hangzhou Red Cross Hospital, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Hangzhou Red Cross Hospital, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"107325","DOI":"10.1016\/j.ijid.2024.107325","article-title":"Insights from the 2024 WHO global tuberculosis report - more comprehensive action, innovation, and investments required for achieving WHO end 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