{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:39Z","timestamp":1781585679448,"version":"3.54.5"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Knee osteoarthritis (KOA) is a prevalent degenerative joint disease, and gut microbiota dysbiosis in its pathogenesis is a research hotspot. This study performed a traditional meta-analysis to systematically evaluate probiotics\u2019 efficacy (for KOA symptoms, strain-specific superiority) and safety, using RCT data from Chinese and English databases. Stata 17.0 and RevMan 5.4 analyzed outcomes including patient-reported pain (Visual Analog Scale (VAS), WOMAC pain), joint stiffness, function limitation, serum High-sensitivity C-reactive protein (hs-CRP), and safety. Probiotics showed no significant adverse event differences vs. placebo, with no serious safety issues. Results suggest probiotics have potential for KOA, especially\n                    <jats:italic>Saccharomyces boulardii<\/jats:italic>\n                    and\n                    <jats:italic>LatiLactobacillus sakei LB-P12<\/jats:italic>\n                    . However, small sample sizes and limited studies weaken evidence; further research is needed.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1799943","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:28:08Z","timestamp":1781584088000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.3389","volume":"13","author":[{"given":"Keye","family":"Chen","sequence":"first","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longkang","family":"Cui","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang Chinese Medical University","place":["Hangzhou, 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