{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:05:10Z","timestamp":1779433510180,"version":"3.53.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Objective<\/jats:title>\n To systematically evaluate the application value and implementation effectiveness of a Failure Mode and Effects Analysis (FMEA)-based bundled management strategy in the precise prevention and control of hospital-acquired infections (HAIs) in the Intensive Care Unit (ICU) of a specialized oncology hospital.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A single-cohort study with pre-post measurements was conducted in the ICU of a tertiary Grade A specialized oncology hospital. The pre-implementation period included 2,975 patients admitted from January to December 2024, receiving conventional HAI prevention and control measures. The post-implementation period included 1,522 patients admitted from January to June 2025, who received an FMEA-driven bundled management strategy in addition to conventional measures. A multidisciplinary FMEA team identified potential failure modes using the \u201cMan, Machine, Material, Method, Environment, Measurement\u201d framework. Risks were quantified using the Risk Priority Number (RPN = Severity \u00d7 Occurrence \u00d7 Detection), and high-risk failure modes (RPN \u2265 80) were targeted with multi-dimensional bundled interventions (e.g., multi-departmental coordination, stratified training, hand hygiene improvement). Outcomes included HAI incidence, device-associated infection rates [Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection (CLABSI), Catheter-Associated Urinary Tract Infection (CAUTI)], hand hygiene compliance, and environmental cleaning quality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Following the intervention, overall HAI incidence decreased significantly from 2.6% (77 infections in 2,975 patients) to 1.6% (25 infections in 1,522 patients) (\u03c7\n 2<\/jats:sup>\n = 4.062,\n P<\/jats:italic>\n &lt; 0.05), a relative reduction of 36.7%. Device-associated infection rates showed notable control: CAUTI decreased from 0.57\u2030 to 0, VAP from 1.69\u2030 to 0, and CLABSI remained low (0.28\u20130.27\u2030). Hand hygiene compliance among healthcare workers increased from 72.2 to 88.9% (\u03c7\n 2<\/jats:sup>\n = 4.578,\n P<\/jats:italic>\n &lt; 0.05), an improvement of 23.1%. The 24-h removal rate of fluorescent markers for environmental cleaning assessment surged from 36.1 to 76.0%. RPN values for all six high-risk failure modes decreased substantially, with reductions ranging from 28.0 to 75.0%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The FMEA-based bundled management strategy effectively identifies and mitigates high-risk vulnerabilities in ICU HAI prevention and control. It significantly reduces HAI and device-associated infection rates while improving hand hygiene compliance and environmental disinfection quality. This model provides an evidence-based paradigm for precise HAI prevention and control in specialized oncology hospital ICUs and holds high potential for broader clinical application.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1801802","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:09:52Z","timestamp":1779430192000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of failure mode and effects analysis combined with bundled management measures in reducing ICU-acquired infections"],"prefix":"10.3389","volume":"13","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health, Xinjiang Medical University","place":["\u00dcr\u00fcmqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuluke","family":"Ku","sequence":"additional","affiliation":[{"name":"College of Medical Engineering Technology, Xinjiang Medical University","place":["\u00dcr\u00fcmqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Jia","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University","place":["\u00dcr\u00fcmqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University","place":["\u00dcr\u00fcmqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinjiang Medical University","place":["\u00dcr\u00fcmqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinjiang Medical University","place":["\u00dcr\u00fcmqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00103-024-03882-w","article-title":"Automated surveillance and risk prediction with the aim of risk-stratified infection control and prevention (RISK PRINCIPE).","volume":"67","author":"Marschollek","year":"2024","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz."},{"key":"B2","first-page":"448","article-title":"Application of evidence-based bundled intervention strategies in the control of multidrug-resistant organism infections in the ICU.","volume":"38","author":"Alp","year":"2022","journal-title":"J. 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