{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:35:36Z","timestamp":1776753336589,"version":"3.51.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Health Department","award":["2025KY1543"],"award-info":[{"award-number":["2025KY1543"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>For patients with locally advanced non-small cell lung cancer (NSCLC) who are intolerant to concurrent chemoradiotherapy, sequential chemotherapy followed by radiotherapy is a standard alternative treatment. However, disease progression after first-line chemotherapy results in poor prognosis, and radiotherapy alone often fails to achieve ideal tumor control. Notably, these patients exhibit a higher incidence of obstructive atelectasis, which further worsens clinical outcomes. This study reports two unique cases of locally advanced NSCLC with obstructive atelectasis after first-line chemotherapy failure. Both patients received combined therapy with radiotherapy and drug-eluting bead bronchial artery chemoembolization (DEB-BACE). Results demonstrated preliminary control of atelectasis in both patients, followed by long-term remission post-treatment. These findings suggest that radiotherapy combined with DEB-BACE may be a promising potential strategy for locally advanced NSCLC patients accompanied by atelectasis.<\/jats:p>","DOI":"10.3389\/fmed.2026.1805214","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:35:28Z","timestamp":1776749728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy combined with DEB-BACE for locally advanced lung cancer with obstructive atelectasis following first-line treatment failure: case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Bin","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Pulmonary Vascular Center, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University","place":["Huzhou, China"]},{"name":"Department of Interventional Therapy, Huzhou Central Hospital, Fifth School of Clinical Medicine 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