{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:03:30Z","timestamp":1784099010944,"version":"3.55.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>A 38-year-old woman with a &amp;gt;10-year history of heavy alcohol consumption presented with acute-onset jaundice and massive hepatomegaly. Laboratory tests revealed a cholestatic-pre-dominant liver injury pattern with extreme \u03b3-glutamyl transferase elevation (&amp;gt;1,000 U\/L) and marked hyperferritinemia (&amp;gt;1,500 ng\/ml). Imaging excluded extrahepatic biliary obstruction. Liver biopsy demonstrated steatohepatitis with ductular reaction and stage F2 fibrosis. Metagenomic next-generation sequencing (mNGS) was negative for infectious pathogens. After alcohol abstinence, metabolic intervention, a short empiric corticosteroid course, and supportive therapy, liver function gradually improved. This case highlights a reversible cholestatic phenotype in alcohol-associated steatotic liver injury with metabolic dysfunction and suspected secondary iron overload.<\/jats:p>","DOI":"10.3389\/fmed.2026.1805756","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:03:30Z","timestamp":1784095410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic dysfunction\u2013associated steatotic liver disease with alcohol- and iron overload\u2013related cholestatic liver injury: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Bin","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Yanbian University","place":["Yanji, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, 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