{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:50:13Z","timestamp":1792810213082,"version":"4.5.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Introduction<\/jats:title>\n \n Previous studies have shown that Aquamin\n \u00ae<\/jats:sup>\n , a multi-mineral extract from red marine algae, enhances gut barrier protein expression in the human colon. Here we carried out an exploratory study aimed at generating support for Aquamin\n \u00ae<\/jats:sup>\n \u2019s ability to affect gastrointestinal permeability.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Subjects with mild ulcerative colitis (UC) or UC in remission and healthy controls were enrolled in an open-label, pilot-phase trial and received Aquamin\n \u00ae<\/jats:sup>\n capsules (800 mg calcium\/day) for 90 days. Intestinal permeability was evaluated before and after the 90-day intervention by urinary mannitol excretion after ingestion of a 5 g mannitol solution, with collections across several time intervals (pre-drink, 0\u20132 h, 2\u20138 h, and 8\u201324 h). The primary outcome was the change in mannitol excretion. Serum samples were also collected to assess liver and renal function.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In this pilot study (NCT04855799), which included UC patients and healthy controls (\n n<\/jats:italic>\n = 8 per group), baseline urine mannitol levels in the 0\u20132 h sample were 54% higher in UC patients compared to healthy subjects (\n p<\/jats:italic>\n = 0.006). Following 90 days of Aquamin\n \u00ae<\/jats:sup>\n supplementation, urinary mannitol levels in UC patients decreased by 28, 26, and 41% at the 0\u20132 h, 2\u20138 h, and 8\u201324 h time points, respectively; the reduction at the 0\u20132 h interval reached statistical significance (\n p<\/jats:italic>\n = 0.015). Overall, Aquamin\n \u00ae<\/jats:sup>\n supplementation reduced total post-intervention mannitol excretion by 29% (\n p<\/jats:italic>\n = 0.024). Aquamin\n \u00ae<\/jats:sup>\n was well tolerated, with no serious adverse events reported. Consistent with our earlier findings, the serum metabolic panel revealed a modest but statistically significant reduction in alkaline phosphatase levels after 90 days of intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Results from this exploratory study provide preliminary evidence that Aquamin\n \u00ae<\/jats:sup>\n supplementation is associated with improved gut barrier function in UC patients. These findings support further investigation of Aquamin\n \u00ae<\/jats:sup>\n as a safe and promising adjunct to current UC management strategies, with potential utility as a barrier therapy in UC.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n \n https:\/\/clinicaltrials.gov\/study\/NCT04855799<\/jats:ext-link>\n , identifier NCT04855799.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1805900","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:37:27Z","timestamp":1782103047000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A multi-mineral intervention is associated with improved intestinal permeability in patients with ulcerative colitis: results from a pilot trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Muhammad N.","family":"Aslam","sequence":"first","affiliation":[{"name":"Department of Pathology, University of 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