{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:06:56Z","timestamp":1776834416532,"version":"3.51.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Pyoderma gangrenosum (PG) is a rare, chronic, autoinflammatory neutrophilic dermatosis. Its typical clinical manifestations include painful papules and pustules surrounded by erythema on the lower extremities and trunk, which gradually progress to form well-demarcated, painful ulcers with undermined edges. Due to impaired skin barrier function, prolonged wound exposure, and the frequent need for immunosuppressive therapy, PG patients are highly susceptible to secondary infections. We report here a clinical case of successful treatment with glucocorticoids and voriconazole, combined with multiple sessions of negative-pressure wound therapy and skin grafting, in a patient with cutaneous\n                    <jats:italic>Aspergillus flavus<\/jats:italic>\n                    infection and possible pyoderma gangrenosum.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1806433","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:31:40Z","timestamp":1776832300000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Probable pyoderma gangrenosum complicated with cutaneous Aspergillus flavus infection: case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Shaoqin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhui","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00281-025-01064-7","article-title":"Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment","volume":"47","author":"Moltrasio","year":"2025","journal-title":"Semin Immunopathol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3390\/pathogens10060643","article-title":"Aspergillus genus and its various human superficial and cutaneous features","volume":"10","author":"Merad","year":"2021","journal-title":"Pathogens"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3390\/jof11040281","article-title":"New challenges in the diagnosis and treatment of primary cutaneous aspergillosis in extensive pediatric burns","volume":"11","author":"Nacea","year":"2025","journal-title":"J Fungi (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/imj.15591","article-title":"Consensus guidelines for the diagnosis and management of invasive aspergillosis, 2021","volume":"51","author":"Douglas","year":"2021","journal-title":"Intern Med J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"6924","DOI":"10.3390\/jcm11236924","article-title":"Treatment strategy for pyoderma gangrenosum: skin grafting with immunosuppressive drugs","volume":"11","author":"Nishimura","year":"2022","journal-title":"J Clin Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/wound.2020.1160","article-title":"Surgical treatment of pyoderma gangrenosum with negative pressure wound therapy and skin grafting, including xenografts: personal experience and comprehensive review on 161 cases","volume":"9","author":"Eisendle","year":"2020","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e14943","DOI":"10.1111\/iwj.14943","article-title":"The role of split-thickness skin grafting in the treatment of vasculitic and pyoderma gangrenosum ulcers in a multidisciplinary wound centre","volume":"21","author":"Suoniemi","year":"2024","journal-title":"Int Wound J"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.12968\/jowc.2016.25.11.617","article-title":"Biological effects and clinical application of negative pressure wound therapy: a review","volume":"25","author":"Nie","year":"2016","journal-title":"J Wound Care"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jtv.2023.06.010","article-title":"The influence of negative pressure wound therapy on bacterial and fungal growth","volume":"32","author":"Biermann","year":"2023","journal-title":"J Tissue Viability"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1806433\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:31:51Z","timestamp":1776832311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1806433\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":9,"alternative-id":["10.3389\/fmed.2026.1806433"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1806433","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"article-number":"1806433"}}