{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:37:11Z","timestamp":1776926231008,"version":"3.51.2"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study aims to analyze the clinical factors affecting embryo quality and quantity in endometriosis patients undergoing\n                      <jats:italic>in vitro<\/jats:italic>\n                      fertilization\/intracytoplasmic sperm injection and embryo transfer (IVF\/ICSI-ET), thereby providing a reference for the clinical prediction of embryonic development outcomes in this patient population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Univariate logistic regression was performed to select variables (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05), which were then entered into a multivariate logistic regression model to develop a predictive model for the likelihood of obtaining a sufficient number of high-quality embryos. A predictive nomogram was constructed based on the findings from the univariate and multivariate analyses. Restricted cubic splines were employed to identify potential non-linear relationships and threshold effects concerning ovarian reserve-related parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The model demonstrated robust discriminative ability, with area under the curve values of 0.765 (95% CI: 0.749\u20130.769) in the training set and 0.776 (95% CI: 0.747\u20130.789) in the validation set. Subgroup analyses further revealed that endometriomas represent a pivotal phenotype adversely affecting both the yield of oocytes and the rate of high-quality embryos.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti-M\u00fcllerian Hormone level, Antral Follicle Count, the presence of bilateral endometriomas, and the utilization of gonadotropin-releasing hormone (GnRH) agonist pre-treatment serve as robust indicators for predicting oocyte yield in patients with endometriosis. The nomogram incorporating these factors provides a practical tool for the early prognostication of ovarian response, thereby offering valuable insights for formulating personalized treatment strategies. GnRH agonist administration demonstrates efficacy in improving clinical outcomes of IVF\/ICSI cycles in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1808405","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:37:57Z","timestamp":1776922677000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of risk factors compromising embryo quality and quantity in patients with endometriosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Hanhong","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil Steril"},{"key":"B2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.5935\/1518-0557.20190029","article-title":"Ethiopathogenic mechanisms of endometriosis-related 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