{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:34:48Z","timestamp":1775068488027,"version":"3.50.1"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Pediatric Chronic Myeloid Leukemia (CML), a rare hematologic malignancy, accounts for only 2\u20133% of cases of leukemia in pediatric patients. The case presented here is of a previously healthy 13-year-old male, who came to the emergency department with increasing fatigue, abdominal distention, and discomfort. On examination, he was pale with significant splenomegaly. His investigation findings included marked leukocytosis (WBC\u202f&amp;gt;\u202f600\u202f\u00d7\u202f10\n                    <jats:sup>9<\/jats:sup>\n                    \/L), severe anemia (Hb 5\u202fg\/dL), along with thrombocytosis (Platelets\u202f&amp;gt;\u202f1,530\u202f\u00d7\u202f10\n                    <jats:sup>9<\/jats:sup>\n                    \/L). The diagnosis was made by peripheral smear and bone marrow biopsy, showing Chronic Phase CML with less than 3% blasts along with intense granulocytic hyperplasia. Molecular studies by PCR identified the BCR:ABL1 fusion transcript. The initial treatment approach emphasized cytoreduction therapy with hydroxyurea, intravenous fluid administration, and preventive medication with allopurinol to protect against the risk of tumor lysis syndrome. After the patient became stabilized, imatinib, a first-line tyrosine kinase inhibitor, was started. The supportive care consisted of transfusion support and gastrointestinal protection. The patient responded quite well to therapy and was therefore discharged with instructions for further follow-up care. As highlighted by this case, the importance of prompt diagnosis, the initiation of cytoreduction therapy, and the use of molecular therapy in treating CML in children cannot be neglected. CML in children is an uncommon but curable form of leukemia.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1809227","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:10:18Z","timestamp":1775063418000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Chronic myeloid leukemia in a 13-year-old\u2014a rare pediatric case of extreme hyperleukocytosis in chronic phase"],"prefix":"10.3389","volume":"13","author":[{"given":"Mohammad","family":"Asees","sequence":"first","affiliation":[{"name":"Department of Allied and Applied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University","place":["Nablus, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toleen","family":"Abdalhaq","sequence":"additional","affiliation":[{"name":"Department of Allied and Applied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University","place":["Nablus, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Allied and Applied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University","place":["Nablus, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.yapd.2023.04.002","article-title":"Chronic myeloid leukemia in children and adolescents","volume":"70","author":"Moran Gotesman","year":"2023","journal-title":"Adv Pediatr Infect Dis"},{"key":"ref2","volume-title":"Childhood Chronic Myeloid Leukemia Treatment \u2013 Health Professional Version","year":"2024"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e82673","DOI":"10.7759\/cureus.82673","article-title":"Clinico-hematological profile of children and adolescents with chronic myeloid leukemia: a study at a tertiary care institute in India","volume":"17","author":"Kumar","year":"2025","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41375-025-02543-4","article-title":"Management of children and adolescents with chronic myeloid leukemia in chronic phase: recommendations from the international pediatric CML expert panel","volume":"39","author":"Millot","year":"2025","journal-title":"Leukemia"},{"key":"ref5","article-title":"BCR-ABL positive childhood chronic myeloid leukemia: a case report","volume":"7","author":"Choudhry","year":"2017","journal-title":"Case Reports in Clinical 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international pediatric CML expert panel recommendations","volume":"37","author":"Naumann-Bartsch","year":"2023","journal-title":"Leukemia"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00277-022-05024-1","article-title":"Prevalence of anemia at diagnosis of pediatric chronic myeloid leukemia and prognostic impact on the disease course","volume":"102","author":"Delehaye","year":"2023","journal-title":"Ann Hematol"}],"container-title":["Frontiers in 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