{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:27:08Z","timestamp":1786602428181,"version":"build-2736575974"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Background<\/jats:title>\n \n Do endometrial pattern types show an association with clinical outcomes in an IVF-ET cohort with pattern diversity, and do endometrial thickness and serum E\n 2<\/jats:sub>\n and P\n 4<\/jats:sub>\n levels measured on the day of endometrial assessment provide additional predictive value regarding reproductive outcomes?\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective HRT-FET study included 237 euploid blastocyst transfer cycles. The effects of endometrial pattern types (Type A\u2013B\u2013C) on pregnancy, miscarriage, and live birth were evaluated; the relationship between endometrial thickness and hormonal parameters and reproductive outcomes was analyzed; and predictive performance was assessed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant differences were observed between endometrial pattern types for total pregnancy, biochemical pregnancy, miscarriage, and live birth rates (\n p<\/jats:italic>\n = 0.004), with Type A showing the highest live birth rate. Endometrial thickness did not differ across pattern groups (\n p<\/jats:italic>\n = 0.3819) or pregnancy outcome (\n p<\/jats:italic>\n = 0.5676). Thickness categories showed significant distribution difference (\n p<\/jats:italic>\n = 0.014), with higher live birth rates in &gt;10.1 mm. ROC analyses indicated no predictive value for endometrial thickness in pregnancy (AUC = 0.505; cut-off 8.75 mm) or live birth (AUC = 0.5103; cut-off 11.85mm). E\n 2<\/jats:sub>\n and P\n 4<\/jats:sub>\n levels did not differ between pattern types (E\n 2<\/jats:sub>\n p<\/jats:italic>\n = 0.3819 and\n p<\/jats:italic>\n = 0.2646; P\n 4<\/jats:sub>\n p<\/jats:italic>\n = 0.0799 and\n p<\/jats:italic>\n = 0.2928), and ROC analyses for E\n 2<\/jats:sub>\n showed limited predictive power in Type A (AUC = 0.5505; cut-off 279.5pg\/ml) and Type B (AUC = 0.5382; cut-off 369.5pg\/ml).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Endometrial pattern may be associated with clinical outcomes, whereas endometrial thickness and serum E\n 2<\/jats:sub>\n levels demonstrated limited discriminatory power. These findings highlight the heterogeneity in the existing literature and indicate that their role in decision-making during HRT-FET cycles should be reconsidered.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1809726","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:32:37Z","timestamp":1786599157000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic role of endometrial pattern compared with thickness and estradiol in euploid HRT-FET cycles"],"prefix":"10.3389","volume":"13","author":[{"given":"Nuri","family":"Peker","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assisted Reproductive Technologies Unit, Ac\u0131badem Maslak Hospital","place":["\u0130stanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fen","family":"Y\u00fccet\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assisted Reproductive Technologies Unit, Ac\u0131badem Maslak Hospital","place":["\u0130stanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"T\u0131\u011fl\u0131","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, K\u00fctahya Health Sciences University","place":["K\u00fctahya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Karaosmano\u011flu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assisted Reproductive Technologies Unit, Ac\u0131badem Maslak Hospital","place":["\u0130stanbul, 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