{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:46:00Z","timestamp":1776919560689,"version":"3.51.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adenoma of the non-pigmented ciliary epithelium (ANPCE) is a rare intraocular tumor that is frequently misdiagnosed due to its concealed location and non-specific presentation. This report describes the diagnostic challenges of ANPCE and presents a novel \u201ctriple procedure\u201d surgical approach that integrates partial lamellar sclerouvectomy (PLSU) with concurrent phacoemulsification and intraocular lens (IOL) implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 39-year-old Asian woman presented with a two-month history of progressive visual decline in the left eye, which had been initially misdiagnosed as a cataract at a referral hospital. Slit-lamp examination revealed a mass posterior to the iris at the 10\u201311 o\u2019clock position. Multimodal imaging, including ultrasound biomicroscopy (UBM) and magnetic resonance imaging (MRI), demonstrated a ciliary body lesion. An incisional biopsy with immunohistochemical analysis confirmed the diagnosis of ANPCE. The patient subsequently underwent localized tumor resection via PLSU combined with phacoemulsification and IOL implantation. Postoperatively, the best-corrected visual acuity (BCVA) improved to 20\/22 (0.9), and no recurrence was observed during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unexplained unilateral cataract warrants meticulous slit-lamp and UBM evaluation to exclude occult ciliary body tumors. A staged diagnostic approach may reduce iatrogenic risk, while a triple procedure can achieve complete tumor clearance and restore visual function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1817040","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:21:05Z","timestamp":1776918065000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of adenoma of the nonpigmented ciliary epithelium managed with a triple procedure: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Yangyang","family":"Jin","sequence":"first","affiliation":[{"name":"The Affiliated Eye Hospital of Nanjing Medical University","place":["Nanjing, China"]},{"name":"The Fourth School of Clinical Medicine, Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujia","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital of Nanjing Medical University","place":["Nanjing, China"]},{"name":"The Fourth School of Clinical Medicine, Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital of Nanjing Medical University","place":["Nanjing, China"]},{"name":"The Fourth School of Clinical Medicine, Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital of Nanjing Medical University","place":["Nanjing, China"]},{"name":"The Fourth School of Clinical Medicine, Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyan","family":"Ding","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital of Nanjing Medical University","place":["Nanjing, China"]},{"name":"The Fourth School of Clinical Medicine, Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.4103\/ijo.IJO_845_19","article-title":"Intraocular medulloepithelioma \u2013 a review of clinical features, DICER 1 mutation, and management","volume":"67","author":"Tadepalli","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1631\/jzus.2007.B0612","article-title":"Adenoma of nonpigmented epithelium in ciliary body: literature review and case report","volume":"8","author":"Chen","year":"2007","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1177\/1120672120952645","article-title":"Diagnosis and long-term monitoring of adenomas of the ciliary body epithelium by ultrasound biomicroscopy","volume":"31","author":"M\u00e9ndez-Mart\u00ednez","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"104288","DOI":"10.1016\/j.jfo.2024.104288","article-title":"Cataract as the first manifestation of an adenoma of the nonpigmented epithelium of the ciliary body","volume":"47","author":"Garc\u00eda-L\u00f3pez","year":"2024","journal-title":"J Fr Ophtalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1016\/s0161-6420(96)30393-x","article-title":"Acquired neoplasms of the nonpigmented ciliary epithelium (adenoma and adenocarcinoma)","volume":"103","author":"Shields","year":"1996","journal-title":"Ophthalmology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12886-024-03444-3","article-title":"Local resection via partial lamellar sclerouvectomy for ciliary body tumors \u2014 a case series","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1038\/eye.2012.145","article-title":"Ciliary-body adenoma of the non-pigmented epithelium with rubeosis iridis treated with plaque brachytherapy and bevacizumab","volume":"26","author":"Papastefanou","year":"2012","journal-title":"Eye"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/S0161-6420(83)34353-0","article-title":"Adenoma of the nonpigmented epithelium of the ciliary body","volume":"90","author":"Shields","year":"1983","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1001\/archopht.117.1.113","article-title":"Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris","volume":"117","author":"Cursiefen","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000497033","article-title":"Rare histological type of adenoma of the nonpigmented ciliary epithelium","volume":"10","author":"Ishiahara","year":"2019","journal-title":"Case Rep Ophthalmol"},{"key":"ref11","first-page":"12008","article-title":"Adenoma of the non-pigmented epithelium of the ciliary body with smooth muscle differentiation: a unique case report","volume":"9","author":"Sun","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00417-014-2928-4","article-title":"Acquired adenoma of the nonpigmented ciliary epithelium: analysis of five cases","volume":"253","author":"Yan","year":"2015","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"101871","DOI":"10.1016\/j.ajoc.2023.101871","article-title":"Adenoma of the nonpigmented ciliary epithelium presenting as glaucoma","volume":"32","author":"St\u00e5lhammar","year":"2023","journal-title":"Am J Ophthalmol Case Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"01","DOI":"10.1111\/j.1755-3768.2014.S103.x","article-title":"The coexistence of uveal melanoma and non-pigment ciliary body epithelium adenoma in one eye","volume":"92","author":"Markiewicz","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ajoc.2018.01.015","article-title":"Optical coherence tomography angiography of a pigmented fuchs\u2019 adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma","volume":"9","author":"Nagarkatti-Gude","year":"2018","journal-title":"Am J Ophthalmol Case Rep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1658817","DOI":"10.3389\/fmed.2025.1658817","article-title":"Cytokine profiles in the aqueous humor of uveal melanoma: implications for tumor progression and radiation response","volume":"12","author":"Ding","year":"2025","journal-title":"Front Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.3390\/ijms23084256","article-title":"The role of metalloproteinases and their tissue inhibitors on ocular diseases: focusing on potential mechanisms","volume":"23","author":"Caban","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1136\/bjo-2023-323845","article-title":"Adenomas of the ciliary body epithelium: clinics, histopathology and management","volume":"108","author":"Zheng","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"768635","DOI":"10.3389\/fonc.2022.768635","article-title":"Surgical resection of intraocular tumors (partial transscleral sclerouvectomy combined with mircoinvasive vitrectomy and reconstruction of the eyeball) in asian patients: twenty-five years results","volume":"12","author":"Zhou","year":"2022","journal-title":"Front Oncol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.18240\/ijo.2023.07.12","article-title":"Technique of using cionni-modified capsular tension ring in the management of severely traumatic lens subluxation","volume":"16","author":"Jiang","year":"2023","journal-title":"Int J Ophthalmol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4103\/tjo.tjo_26_18","article-title":"Forceps-assisted, 10-0 monofilament nylon, suture-guided capsular tension ring insertion in subluxated cataracts","volume":"10","author":"Sethi","year":"2019","journal-title":"Taiwan J Ophthalmol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.3349\/ymj.2016.57.5.1236","article-title":"Effect of co-implantation of a capsular tension ring on clinical outcomes after cataract surgery with monofocal intraocular lens implantation","volume":"57","author":"Park","year":"2016","journal-title":"Yonsei Med J"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ajo.2004.06.087","article-title":"Adenoma arising from nonpigmented ciliary epithelium concomitant with neovascularization of the optic disk and cystoid macular edema","volume":"139","author":"Suzuki","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"348","DOI":"10.4103\/joco.joco_88_24","article-title":"Liquid biopsy and ocular tumors: a review","volume":"36","author":"Chaaya","year":"2025","journal-title":"J Curr Ophthalmol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"102447","DOI":"10.1016\/j.xcrm.2025.102447","article-title":"Aqueous humor biomarkers in ocular oncology: insights and advances","volume":"6","author":"Cheslow","year":"2025","journal-title":"Cell Rep Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/bioengineering12060650","article-title":"OCT in oncology and precision medicine: from nanoparticles to advanced technologies and AI","volume":"12","author":"Daneshpour Moghadam","year":"2025","journal-title":"Bioengineering"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1817040\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:21:06Z","timestamp":1776918066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1817040\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":26,"alternative-id":["10.3389\/fmed.2026.1817040"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1817040","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"article-number":"1817040"}}