{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:02:52Z","timestamp":1792800172010,"version":"4.5.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to systematically review and meta-analyze the efficacy and safety of Lanqin Oral Liquid combined with Western medicine for the treatment of pharyngitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive and systematic literature search was conducted by two independent reviewers across six electronic databases\u2013PubMed, Embase, Web of Science, CNKI, WanFang and VIP. Outcomes included the effective rate, symptoms improvement, C-reactive protein (CRP) levels, and the incidence of adverse events. The Cochrane Risk of Bias tool was adopted to evaluate the quality of the included studies, and RevMan 5.4 and Stata 15.0 software were used for meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 12 studies were included. The effective rate of Lanqin Oral Liquid combined with Western medicine for pharyngitis was significantly higher than that of Western medicine monotherapy (OR = 3.68, 95% CI [2.55, 5.33],\n                      <jats:italic>Z<\/jats:italic>\n                      = 6.92,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001), with no heterogeneity across studies (I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.73). Compared with Western medicine monotherapy, combination therapy significantly shortened the disappearance time of pharyngeal redness\/swelling, sore throat, and phlegm in patients with acute pharyngitis, and reduced Reflux Symptom Index score and Reflux Finding Score in those with chronic pharyngitis (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). The combination therapy was significantly superior to Western medicine monotherapy in reducing CRP levels (SMD = \u22122.72, 95% CI [\u22123.37, \u22122.07],\n                      <jats:italic>Z<\/jats:italic>\n                      = 8.19,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). The incidence of adverse events showed no significant difference between the two groups (OR = 0.63, 95% CI [0.28, 1.45],\n                      <jats:italic>Z<\/jats:italic>\n                      = 1.08,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.28).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For pharyngitis patients, the combination of Lanqin Oral Liquid and Western medicine may provide better efficacy compared with Western medicine monotherapy, and its safety profile should be interpreted with caution owing to limited available evidence.<\/jats:p>\n                  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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Huashan Hospital Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"Cd004406","DOI":"10.1002\/14651858.CD004406.pub5","article-title":"Different antibiotic treatments for group A streptococcal pharyngitis.","volume":"3","author":"van Driel","year":"2021","journal-title":"Cochrane Database Syst Rev."},{"key":"B2","volume-title":"Pharyngitis.","author":"Wolford","year":"2026"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1625547","DOI":"10.3389\/fphar.2025.1625547","article-title":"Xiao\u2019er Fengreqing oral liquid versus Xiao\u2019er Yanbian granules for pediatric acute pharyngitis\/tonsillitis 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