{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:52:17Z","timestamp":1776664337196,"version":"3.51.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Giant endometrial polyps (EPs) are rare in postmenopausal women without hormonal exposure. This study aimed to summarize their clinical presentation and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient<\/jats:title>\n                    <jats:p>Fifteen postmenopausal women with primary giant EPs were included: one case from our center and fourteen additional cases were retrieved from Pubmed, Web of science and Embase databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The fifteen patients ranged in age from 55 to 70\u202fyears, with polyp diameters ranging from 4.0 to 12.0\u202fcm. The most common symptom was postmenopausal bleeding (PMB). Surgical intervention was performed in all cases: six patients underwent hysteroscopic polypectomy, eight received total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO) and one underwent dilation and curettage D&amp;amp;C. Most polyps (11\/15) were benign on histology and exhibited cystic dilatation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Giant EPs in postmenopausal women are rare but predominantly benign, especially in the absence of hormonal exposure. Transvaginal sonography (TVS) is the first-line modality for initial evaluation. Diagnostic hysteroscopy with complete polypectomy remains the gold standard, enabling accurate histopathological assessment and avoiding unnecessary hysterectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1821347","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:23:32Z","timestamp":1776662612000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant endometrial polyp in postmenopausal women without hormonal exposure: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Danlin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Tongren People's Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Tongren People's Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Tongren People's Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Tongren People's Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"992","DOI":"10.3109\/00016349.2010.493196","article-title":"Treatment of endometrial polyps: a systematic review","volume":"89","author":"Lieng","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e11457","DOI":"10.1097\/MD.0000000000011457","article-title":"Prevalence of abnormal uterine bleeding according to new International Federation of Gynecology and Obstetrics classification in Chinese women of reproductive age: a cross-sectional study","volume":"97","author":"Sun","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4103\/jmh.jmh_188_24","article-title":"Silent intruders: a case report of concurrent atypical endometrial polyp with cervical intraepithelial neoplasia","volume":"16","author":"Devalla","year":"2025","journal-title":"J Midlife Health"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1111\/j.1471-0528.2007.01391.x","article-title":"Endometrial hyperplasia involving endometrial polyps: report of a series and discussion of the significance in an endometrial biopsy specimen","volume":"114","author":"Kelly","year":"2007","journal-title":"BJOG"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1186\/s12905-024-03406-3","article-title":"Malignancy risk factors based on endometrial polyp","volume":"24","author":"Cetin","year":"2024","journal-title":"BMC Womens Health"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/S0029-7844(00)01196-0","article-title":"Tamoxifen treatment and gynecologic side effects: a review","volume":"97","author":"Mourits","year":"2001","journal-title":"Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"212","DOI":"10.4103\/jmh.JMH_82_18","article-title":"Giant endometrial polyp: an enigma in a postmenopausal woman","volume":"9","author":"Sharma","year":"2018","journal-title":"J Midlife Health"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4274\/tao.2022.2022-01","article-title":"CARE (CAse REport) guidelines: a recipe for more transparent case reports","volume":"60","author":"Bayram","year":"2022","journal-title":"Turk Arch Otorhinolaryngol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.4103\/jfmpc.jfmpc_1085_19","article-title":"Is transvaginal ultrasound an appropriate screening tool for endometrial cancer in asymptomatic postmenopausal women? 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