{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:59:05Z","timestamp":1780981145580,"version":"3.54.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>While the lymphocyte-to-C-reactive protein ratio (LCR) is prognostic in critical illness, its role in geriatric patients with severe dysphagia requiring artificial nutrition is unclear. We evaluated its association with mortality in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Utilizing the Dryad Digital Repository, we conducted a retrospective secondary analysis of a single-center study enrolling 248 patients (January 2014\u2013January 2017). The association between log\n                      <jats:sub>2<\/jats:sub>\n                      (LCR) and mortality was evaluated using Cox proportional hazards models, and survival was assessed via Kaplan\u2013Meier curves. Predictive performance across different time points was assessed via time-dependent ROC and landmark analyses. ROC AUC and Boruta feature selection were used to compare LCR with other indices. Subgroup analyses were conducted to confirm robustness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The secondary analysis comprised 248 patients (151 females; mean age: 83.0 \u00b1 9.3 years). Higher log\n                      <jats:sub>2<\/jats:sub>\n                      (LCR) levels were associated with lower mortality (adjusted HR: 0.89, 95% CI: 0.83\u20130.97). Patients in the highest log\n                      <jats:sub>2<\/jats:sub>\n                      (LCR) tertile exhibited a 55% lower risk of death compared to those in the lowest tertile (adjusted HR: 0.45, 95% CI: 0.27\u20130.76;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003,\n                      <jats:italic>P<\/jats:italic>\n                      for trend = 0.003). Median survival times increased across tertiles (214, 359 days, and not reached;\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.0001). Landmark analyses at 360 days demonstrated a pronounced survival benefit for the highest tertile (HR: 0.15; 95% CI: 0.077\u20130.286). ROC analyses and Boruta feature selection confirmed the prognostic advantage of LCR, and sensitivity analyses verified the overall robustness of these findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In geriatric patients with severe dysphagia requiring artificial nutrition, LCR shows an inverse association with mortality. While its predictive value may weaken over extended follow-up, LCR remains a robust indicator for 1-year mortality. Early LCR assessment could help identify high-risk patients, potentially guiding prompt interventions to improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1823539","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:28:17Z","timestamp":1780979297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of the lymphocyte-to-C-reactive protein ratio for mortality in geriatric patients with severe dysphagia requiring artificial nutrition: a retrospective secondary analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Chong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Affiliated Jianhu Hospital of Xinglin College, Nantong University","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Affiliated Jianhu Hospital of Xinglin College, Nantong University","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Affiliated Jianhu Hospital of Xinglin College, Nantong University","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s41999-023-00773-2","article-title":"Dysphagia in older patients admitted to a rehabilitation setting after an acute hospitalization: the role of delirium","volume":"14","author":"Grossi","year":"2023","journal-title":"Eur Geriatr Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12888-024-05520-w","article-title":"Does ICU admission dysphagia independently contribute to delirium risk in ischemic stroke patients? 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