{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:04:39Z","timestamp":1784009079764,"version":"3.55.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Background<\/jats:title>\n The high prevalence of chronic obstructive pulmonary disease (COPD) poses a significant social burden. Emphysema is a basic pathological change associated with poor lung function in stable COPD. However, few studies have focused on the potential role of emphysema in acute exacerbation of COPD (AECOPD). The current study aimed to explore the correlation between CT-determined emphysema and other main physiological parameters of severe AECOPD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In total 90 hospitalized patients with AECOPD participated in this cross-sectional study. All of them underwent chest CT scans and lung function tests as planned. Emphysema was defined as the percentage of low attenuation areas (LAA) below \u2212950 Hounsfield Units (%LAA\n \u2212950<\/jats:sub>\n ) on inspiratory CT scans. Health-Related Quality of Life (HRQoL) was assessed using four questionnaires, including the St. George\u2019s Respiratory Questionnaire (SGRQ), modified Medical Research Council dyspnea scale, COPD Assessment Test, and EXAcerbation of Chronic Pulmonary Disease Tool (EXACT). Qualified data from 73 patients were included in the analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n %LAA\n \u2212950<\/jats:sub>\n was significantly correlated with spirometry parameters and HRQoL scores. The SGRQ and EXACT scores were significantly positively correlated with %LAA\n \u2212950<\/jats:sub>\n (\n \u03c1<\/jats:italic>\n \u202f=\u202f0.399,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001;\n \u03c1<\/jats:italic>\n \u202f=\u202f0.370,\n p\u202f=<\/jats:italic>\n 0.001, respectively). The ratio of the forced expiratory volume in the first 1\u202fs to the forced vital capacity of the lungs and the percentage of predicted forced expiratory volume in first 1\u202fs, which are functional indicators of airflow limitation, were significantly negatively correlated with %LAA\n \u2212950<\/jats:sub>\n (\n \u03c1<\/jats:italic>\n \u202f=\u202f\u22120.735,\n p<\/jats:italic>\n \u202f&lt;\u202f0.00;\n \u03c1<\/jats:italic>\n \u202f=\u202f\u22120.602,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001, respectively). Based on the stepwise multiple linear regression model showed that FEV\n 1<\/jats:sub>\n \/FVC and age could be predictors of %LAA\n \u2212950<\/jats:sub>\n (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u202f=\u202f0.592,\n F<\/jats:italic>\n \u202f=\u202f50.762,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In patients with severe AECOPD, CT-determined emphysema is associated with decreased lung function and poor HRQoL.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n The study was registered on the Chinese Clinical Trial Registry (registration number: ChiCTR2000033101).<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1825493","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:37:43Z","timestamp":1784007463000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between CT-determined emphysema and the severity of acute exacerbation of chronic obstructive pulmonary disease: a cross-sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Cheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Xia","family":"Cao","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine, Guangdong Medical University","place":["Zhanjiang, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Hua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Gen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]},{"name":"First School of Clinical Medicine, Guangdong Medical University","place":["Zhanjiang, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"ref1","year":"2025"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/S0140-6736(21)00458-X","article-title":"Improving lung health in low-income and middle-income countries: from challenges to solutions","volume":"397","author":"Meghji","year":"2021","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1513\/pats.200708-126ET","article-title":"Pathogenesis of emphysema: from the bench to the bedside","volume":"5","author":"Sharafkhaneh","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1148\/radiol.2015141579","article-title":"CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner 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