{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:02:31Z","timestamp":1779692551496,"version":"3.53.1"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Automatic transport ventilators (ATVs) are a potential option for ventilating patients experiencing out-of-hospital cardiac arrest (OHCA); however, their tidal volume delivery performance at different pressure limits compared with that of manual ventilation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study with quasi-experimental before-after features included adult patients with nontraumatic OHCA with prehospital advanced airway in Hsinchu county, Taiwan, in 2023. Participants were categorized into three groups: Group 1 (ventilated by ATVs; pressure limit: 45 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O), Group 2 (ventilated by ATVs; pressure limit: 60 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O), and Group 3 [manual ventilation by bag-valve devices (BVDs)]. The inspiratory tidal volume measured using Zoll\n                      <jats:sup>\u00ae<\/jats:sup>\n                      X-series monitors after advanced airway placement in each group was compared using a linear mixed-effect model (LMM). The association between ventilation settings, delivered inspiratory tidal volume, and return of spontaneous circulation (ROSC) was investigated using logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Groups 1, 2, and 3 comprised 41 (23.0%), 80 (44.9%), and 57 (32.0%) patients with OHCA, respectively. In the\n                      <jats:italic>post-hoc<\/jats:italic>\n                      LMM analysis, Group 1 had a significantly higher tidal volume than Group 2 (adjusted difference: 66.84\u202fmL, 95% confidence interval: 21.27\u2013112.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.012). However, no significant differences were found between Groups 1 and 3 or between Groups 2 and 3. No significant association was observed between different ventilation settings or delivered inspiratory tidal volume and prehospital ROSC or any ROSC following resuscitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ATVs demonstrated comparable delivered inspiratory tidal volume to BVD ventilation in this exploratory retrospective cohort. Increasing the pressure limit of ATVs from 45 to 60 cmH2O did not increase delivered inspiratory tidal volume. The optimal pressure settings of ATVs, formal feasibility and implementation outcomes, and their effects on clinical outcomes remain unclear and require prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1826906","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:58Z","timestamp":1779689038000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of prehospital tidal volume delivery performance between automated transport ventilators and bag-valve devices in out-of-hospital cardiac arrest patients: does the pressure limit matter?"],"prefix":"10.3389","volume":"13","author":[{"given":"Chi-Hsin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch","place":["Hsinchu, Taiwan"]},{"name":"Department of Emergency Medicine, College of Medicine, National Taiwan University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Hsun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Life Science, School of Life Science, College of Science, National Taiwan Normal University","place":["Taipei, Taiwan"]},{"name":"Emergency Department, Taipei Hospital, Ministry of Health and Welfare","place":["New Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch","place":["Hsinchu, Taiwan"]},{"name":"Department of Emergency Medicine, College of Medicine, National Taiwan University","place":["Taipei, Taiwan"]},{"name":"Institute of Molecular Medicine, National Tsing Hua University","place":["Hsinchu, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, National Taiwan University","place":["Taipei, Taiwan"]},{"name":"Department of Emergency Medicine, National Taiwan University Hospital","place":["Taipei, Taiwan"]},{"name":"Department of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch","place":["Douliu, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiun-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch","place":["Hsinchu, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Pei-Chuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch","place":["Hsinchu, Taiwan"]},{"name":"Department of Emergency Medicine, College of Medicine, National Taiwan University","place":["Taipei, Taiwan"]},{"name":"Department of Emergency Medicine, National Taiwan University Hospital","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1001\/jama.1961.03040200010003","article-title":"Ventilation and circulation with closed-chest cardiac massage in man","volume":"176","author":"Safar","year":"1961","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/MCC.0000000000000415","article-title":"The past, present, and future of ventilation during cardiopulmonary resuscitation","volume":"23","author":"Chang","year":"2017","journal-title":"Curr Opin Crit Care"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.4187\/respcare.07775","article-title":"Mechanical ventilation management during mechanical chest compressions","volume":"66","author":"Orso","year":"2021","journal-title":"Respir Care"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S366","DOI":"10.1161\/cir.0000000000000916","article-title":"Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"142","author":"Panchal","year":"2020","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.resuscitation.2006.09.012","article-title":"Do we hyperventilate cardiac arrest patients?","volume":"73","author":"O'Neill","year":"2007","journal-title":"Resuscitation"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1080\/10903127.2020.1822481","article-title":"Ventilation in simulated out-of-hospital cardiac arrest resuscitation rarely meets guidelines","volume":"25","author":"Neth","year":"2021","journal-title":"Prehosp Emerg Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13049-021-00921-2","article-title":"Reliability of mechanical ventilation during continuous chest compressions: a crossover study of transport ventilators in a human cadaver model of CPR","volume":"29","author":"Orlob","year":"2021","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.resuscitation.2022.06.003","article-title":"A pilot evaluation of respiratory mechanics during prehospital manual ventilation","volume":"177","author":"Yang","year":"2022","journal-title":"Resuscitation"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"110366","DOI":"10.1016\/j.resuscitation.2024.110366","article-title":"Ventilation during cardiopulmonary resuscitation: a narrative review","volume":"203","author":"van Eijk","year":"2024","journal-title":"Resuscitation"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"110511","DOI":"10.1016\/j.resuscitation.2025.110511","article-title":"Towards a common terminology of ventilation during cardiopulmonary resuscitation","volume":"207","author":"Segond","year":"2025","journal-title":"Resuscitation"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"110288","DOI":"10.1016\/j.resuscitation.2024.110288","article-title":"Cardiac arrest and cardiopulmonary resuscitation outcome reports: 2024 update of the Utstein out-of-hospital cardiac arrest registry template","volume":"201","author":"Grasner","year":"2024","journal-title":"Resuscitation"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1097\/CCM.0b013e3182a63fa0","article-title":"Mechanical ventilation during cardiopulmonary resuscitation with intermittent positive-pressure ventilation, bilevel ventilation, or chest compression synchronized ventilation in a pig model","volume":"42","author":"Kill","year":"2014","journal-title":"Crit Care Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e0127759","DOI":"10.1371\/journal.pone.0127759","article-title":"Chest compression synchronized ventilation versus intermitted positive pressure ventilation during cardiopulmonary resuscitation in a pig model","volume":"10","author":"Kill","year":"2015","journal-title":"PLoS One"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1826906\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:59Z","timestamp":1779689039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1826906\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":13,"alternative-id":["10.3389\/fmed.2026.1826906"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1826906","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"article-number":"1826906"}}