{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:09:50Z","timestamp":1779253790734,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the clinical efficacy of hemoperfusion (HP) plus continuous renal replacement therapy (CRRT) in patients with poisoning-induced acute renal failure (ARF), with particular focus on renal function recovery and immune function modulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and sixteen patients with poisoning-induced ARF admitted to our hospital from March 2022 to March 2025 were enrolled and randomly divided into the single group receiving CRRT alone and the study group receiving HP\u202f+\u202fCRRT. The primary outcome was the reduction in serum creatinine (Scr) at 72\u202fh post-treatment. Secondary outcomes included blood urea nitrogen (BUN), 24-h urine output, time to CRRT independence, proportion of patients achieving complete renal recovery at 28\u202fdays, immune function parameters, inflammatory markers, disease severity scores, clinical outcomes, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combination group presented better renal function recovery, with lower serum creatinine and blood urea nitrogen levels at 48\u202fh, 72\u202fh, and 7\u202fdays post-treatment, and higher 24-h urine output at all time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Time to CRRT independence was significantly shorter in the combination group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and the percentage of patients achieving complete renal recovery at 28\u202fdays was significantly higher (82.8% vs. 62.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.014). At 7\u202fdays post-treatment, the combination group demonstrated significantly improved immune function, with higher CD3\n                      <jats:sup>+<\/jats:sup>\n                      , CD4\n                      <jats:sup>+<\/jats:sup>\n                      , CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD8\n                      <jats:sup>+<\/jats:sup>\n                      ratio, and immunoglobulin levels (IgG, IgA, IgM) (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05 for all), and lower CD8\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Inflammatory markers (CRP, PCT, IL-6) were significantly lower in the combination group at 48 and 72\u202fh (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.05). The combination group also had lower APACHE II and SOFA scores at 7\u202fdays (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), shorter ICU stay (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), shorter hospital stay (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), lower 28-day mortality (10.3% vs. 24.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.048), and fewer adverse events (17.2% vs. 32.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HP combined with CRRT significantly improves renal function recovery and enhances immune function in patients with poisoning-induced ARF compared to CRRT alone, potentially by removing circulating toxins and inflammatory mediators while modulating the systemic inflammatory response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1827840","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:43:09Z","timestamp":1779252189000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impacts of hemoperfusion combined with continuous renal replacement therapy on renal function and immune function in patients with acute renal failure caused by poisoning"],"prefix":"10.3389","volume":"13","author":[{"given":"Hui","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First People's Hospital of Jiande","place":["Jiande, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzhi","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Data Science and Artificial Intelligence, Wenzhou University of Technology","place":["Wenzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First People's Hospital of Jiande","place":["Jiande, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First People's Hospital of Jiande","place":["Jiande, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First People's Hospital of Jiande","place":["Jiande, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/s0140-6736(24)02385-7","article-title":"Acute kidney injury","volume":"405","author":"Ostermann","year":"2025","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1080\/21548331.2021.1882239","article-title":"Acute kidney injury in hospitalized patients with methanol intoxication: National Inpatient Sample 2003-2014","volume":"49","author":"Thongprayoon","year":"2021","journal-title":"Hosp Pract (1995)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/15563650.2023.2262113","article-title":"Clinical and pathological characteristics of acute kidney injury caused by diquat poisoning","volume":"61","author":"Zeng","year":"2023","journal-title":"Clin Toxicol 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