{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:12:23Z","timestamp":1778739143874,"version":"3.51.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Post-transplant\u2013associated complications arising from endothelial injury, such as sinusoidal obstruction syndrome (SOS) and transplant-associated thrombotic microangiopathy (TA-TMA), are associated with high mortality rates following hematopoietic stem cell transplantation (HSCT). Syndecan-1 (SDC1), a cell-surface proteoglycan released into the circulation upon endothelial damage, is a potential biomarker for vascular integrity. We previously demonstrated that elevated serum SDC1 levels were associated with disease severity and poor prognosis in patients with COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study investigated whether longitudinal serum SDC1 kinetics could predict early mortality in HSCT recipients; serial blood samples were collected from 130 patients undergoing hematopoietic stem cell transplantation (HSCT), from the day of HSCT through day 28 post-transplant, to investigate whether serum SDC1 levels could serve as a predictive marker for early mortality within 100\u202fdays after HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the observation period, 12 patients died, of whom 9 deaths were attributed to conditions associated with endothelial injury, including SOS (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2), TA-TMA (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2), and idiopathic pneumonia syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f3). Notably, serum SDC1 levels at Days 0, 14, and 21 after HSCT were significantly higher in patients who died within 100\u202fdays than in those who survived beyond Day 100.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that serum SDC1 has the potential to predict early post-transplant mortality and warrants further validation in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1828404","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:44:25Z","timestamp":1778737465000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Syndecan-1: a potent prognostic biomarker for transplant outcomes"],"prefix":"10.3389","volume":"13","author":[{"given":"Takayuki","family":"Yokokawa","sequence":"first","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Fukatsu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]},{"name":"Department of Hematology, North Fukushima Medical Center","place":["Date, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Yamada","sequence":"additional","affiliation":[{"name":"R&D Center, Shino-Test Corporation","place":["Sagamihara, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ikezoe","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.bbmt.2020.03.002","article-title":"Indications for hematopoietic cell transplantation and immune effector cell therapy: guidelines from the American Society for Transplantation and Cellular Therapy","volume":"26","author":"Kanate","year":"2020","journal-title":"Biol Blood Marrow 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