{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:47:52Z","timestamp":1782712072836,"version":"3.54.5"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate changes in 24-h intraocular pressure (IOP) profiles and gonioscopic findings before and after gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with primary open-angle glaucoma (POAG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case series included 15 patients (25 eyes) with POAG who underwent GATT at the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu University of Traditional Chinese Medicine, between January 2019 and January 2022 and completed pre- and postoperative 24-h IOP monitoring. Postoperative monitoring was performed at 3\u20136 months after surgery, after IOP-lowering medications had been discontinued for at least 7 days. Patients were followed for 2 years. Outcomes included pre- and postoperative 24-h IOP parameters, office IOP and medication burden at baseline and 2 years, and gonioscopic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 24-h IOP peak decreased significantly from 26.16 \u00b1 1.44 mmHg preoperatively to 21.16 \u00b1 0.60 mmHg postoperatively (mean \u00b1 SD;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). The trough IOP decreased from 17.52 \u00b1 0.66 mmHg to 16.25 \u00b1 0.42 mmHg (mean \u00b1 SD;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.098). IOP fluctuation decreased significantly from 8.68 \u00b1 0.98 mmHg to 4.91 \u00b1 0.34 mmHg (mean \u00b1 SD;\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Mean office IOP decreased from 21.58 \u00b1 1.03 mmHg at baseline to 18.45 \u00b1 0.51 mmHg at 2 years (mean \u00b1 SD;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005), while the median number of medications decreased from 3 (2, 4) to 0 (0, 1). Gonioscopy showed no significant change in Spaeth angle grading across quadrants. Peripheral anterior synechiae were significantly more frequent postoperatively in the nasal and temporal quadrants, while trabecular meshwork pigmentation grade changed significantly in the nasal, temporal, and superior quadrants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this small retrospective case series of POAG eyes, GATT was associated with reductions in 24-h IOP peak and fluctuation, sustained office IOP lowering, and marked medication reduction. Gonioscopy showed stable overall angle configuration, more frequent postoperative PAS in the nasal and temporal quadrants, and postoperative changes in trabecular meshwork pigmentation grade in some quadrants. These findings should be interpreted cautiously and confirmed in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1828554","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:39:38Z","timestamp":1782711578000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Twenty-four-hour intraocular pressure profiles and gonioscopic findings after gonioscopy-assisted transluminal trabeculotomy in primary open-angle glaucoma: a retrospective case series"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu University of Traditional Chinese Medicine (Chengdu First People\u2019s Hospital), Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfang","family":"Wu","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suju","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu University of Traditional Chinese Medicine (Chengdu First People\u2019s Hospital), Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu University of Traditional Chinese Medicine (Chengdu First People\u2019s Hospital), Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuzhi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu University of Traditional Chinese Medicine (Chengdu First People\u2019s Hospital), Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1167\/iovs.02-0666","article-title":"Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes.","volume":"44","author":"Liu","year":"2003","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.survophthal.2019.09.004","article-title":"Review of the measurement and management of 24-hour intraocular pressure in patients with glaucoma.","volume":"65","author":"Mansouri","year":"2020","journal-title":"Surv Ophthalmol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bjophthalmol-2021-egsguidelines","article-title":"European Glaucoma Society terminology and guidelines for glaucoma, 5th Edition.","year":"2021","journal-title":"Br J Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"106921","DOI":"10.1016\/j.cmpb.2022.106921","article-title":"Biomechanics of human trabecular meshwork in healthy and glaucoma eyes via dynamic Schlemm\u2019s canal pressurization.","volume":"221","author":"Karimi","year":"2022","journal-title":"Comput Methods Programs Biomed."},{"key":"B5","doi-asserted-by":"publisher","first-page":"9446","DOI":"10.3390\/ijms22179446","article-title":"Fibrotic changes to Schlemm\u2019s canal endothelial cells in glaucoma.","volume":"22","author":"Kelly","year":"2021","journal-title":"Int J Mol Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.ophtha.2020.05.010","article-title":"Twenty-four-Hour Intraocular Pressure-Related Patterns from Contact Lens Sensors in Normal-Tension Glaucoma and Healthy Eyes: The Exploring Nyctohemeral Intraocular Pressure Related Pattern for Glaucoma Management (ENIGMA) Study.","volume":"127","author":"Kim","year":"2020","journal-title":"Ophthalmology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.ophtha.2013.11.001","article-title":"Gonioscopy-assisted transluminal trabeculotomy, ab interno trabeculotomy: technique report and preliminary results.","volume":"121","author":"Grover","year":"2014","journal-title":"Ophthalmology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/IJG.0000000000000956","article-title":"Gonioscopy-assisted transluminal trabeculotomy: an ab interno circumferential trabeculotomy: 24 months follow-up.","volume":"27","author":"Grover","year":"2018","journal-title":"J Glaucoma."},{"key":"B9","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.ogla.2023.01.005","article-title":"Four-year surgical outcomes of gonioscopy-assisted transluminal trabeculotomy in patients with open-angle glaucoma.","volume":"6","author":"Liu","year":"2023","journal-title":"Ophthalmol Glaucoma."},{"key":"B10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12886-025-03930-2","article-title":"Three-year outcomes of gonioscopy-assisted transluminal trabeculotomy for juvenile-onset primary open-angle glaucoma: a retrospective study.","volume":"25","author":"Hu","year":"2025","journal-title":"BMC Ophthalmol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.3390\/jcm9123814","article-title":"Anterior chamber angle assessment techniques: a review.","volume":"9","author":"Riva","year":"2020","journal-title":"J Clin Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.18502\/jovr.v19i1.15443","article-title":"Contemporary approach to narrow angles.","volume":"19","author":"Shalaby","year":"2024","journal-title":"J Ophthalmic Vis Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1727039","DOI":"10.1155\/2016\/1727039","article-title":"Agreement between gonioscopic examination and swept source Fourier domain anterior segment optical coherence tomography imaging.","volume":"2016","author":"Rigi","year":"2016","journal-title":"J Ophthalmol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/IJG.0000000000002183","article-title":"Gonioscopy-assisted transluminal trabeculotomy and goniotomy, with or without concomitant cataract extraction, in steroid-induced and uveitic glaucoma: 24-month outcomes.","volume":"32","author":"Chen","year":"2023","journal-title":"J Glaucoma."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e0199739","DOI":"10.1371\/journal.pone.0199739","article-title":"Pilot study assessing the structural changes in posttrabecular aqueous humor outflow pathway after trabecular meshwork surgery using swept-source optical coherence tomography.","volume":"13","author":"Yoshikawa","year":"2018","journal-title":"PLoS One."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1097\/IJG.0000000000002131","article-title":"Recruitment of temporal aqueous outflow channels after bent needle ab-interno goniectomy demonstrated by aqueous angiography.","volume":"32","author":"Dada","year":"2023","journal-title":"J Glaucoma."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1828554\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:39:39Z","timestamp":1782711579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1828554\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":16,"alternative-id":["10.3389\/fmed.2026.1828554"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1828554","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"article-number":"1828554"}}