{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:34:09Z","timestamp":1777358049823,"version":"3.51.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hubei Provincial Clinical Research Center for Central Nervous System Repair and Functional Reconstruction","award":["2025SJZX019"],"award-info":[{"award-number":["2025SJZX019"]}]},{"name":"Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education","award":["2024MZFS006"],"award-info":[{"award-number":["2024MZFS006"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy of ciprofol versus propofol combined with alfentanil for anesthesia in patients undergoing hysteroscopic transcervical resection of submucosal myomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 208 patients scheduled for hysteroscopic transcervical resection of submucosal myomas were randomly allocated into ciprofol (group C) and propofol (group P) groups after exclusion. All patients received intravenous alfentanil 10\u202f\u03bcg\/kg before induction. The group C received intravenous ciprofol 0.4\u202fmg\/kg, while the group P received intravenous propofol 2.0\u202fmg\/kg. After anesthesia induction, a laryngeal mask airway was inserted. Anesthesia was maintained with a continuous infusion of ciprofol 0.8 mg\/(kg\u00b7h) or propofol 5\u202fmg\/(kg\u00b7h) using a micro-infusion pump until the end of surgery. Mean arterial pressure (MAP), heart rate (HR), and bispectral index (BIS) were recorded at the following time points: Pre-anesthesia (T0), after anesthesia induction (T1), during cervical dilation (T2), during electrosurgical resection (T3), and at the end of surgery (T4). Total dosage of study drug, recovery time, orientation recovery time, visual analogue scale (VAS) scores for uterine contraction pain after awakening, and adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intraoperative decreases in MAP and HR were significantly greater in the group P than in the group C (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The total anesthetic dosage was significantly higher in the group P (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Recovery time and orientation recovery time were longer in the group C compared with the group P (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). VAS scores at 5 and 15\u202fmin after awakening were significantly lower in the ciprofol group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The incidence of injection pain was much higher in Group P than that in Group C (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). The rate of respiratory inhibition was significantly lower in Group C than that in Group P (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ciprofol exhibits comparable efficacy to that of propofol. It has good analgesic activity, more stable hemodynamics, and minimal respiratory disturbance, less injection pain rate in hysteroscopic transcervical resection of submucosal myoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1829147","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:36:31Z","timestamp":1777354591000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical observation of ciprofol versus propofol anesthesia in hysteroscopic electrosurgical resection of submucosal myomas"],"prefix":"10.3389","volume":"13","author":[{"given":"Haibing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]},{"name":"Key Laboratory of Anesthesiology and Resuscitation, Huazhong University of Science and Technology, Ministry of Education","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Pennsylvania State University","place":["University Park, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.jmig.2017.09.002","article-title":"Hysteroscopic isthmoplasty: step-by-step technique","volume":"25","author":"Di Spiezio Sardo","year":"2018","journal-title":"J Minim Invasive Gynecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.rbmo.2018.09.013","article-title":"Hysteroscopic septum resection and reproductive medicine: a SWOT analysis","volume":"37","author":"Checa","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.5468\/ogs.2016.59.3.220","article-title":"Role of vaginal estradiol pretreatment combined with vaginal misoprostol for cervical ripening before operative hysteroscopy in postmenopausal women","volume":"59","author":"Casadei","year":"2016","journal-title":"Obstet Gynecol Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/bcpt.13280","article-title":"ED50 of propofol in combination with low-dose sufentanil for intravenous anaesthesia in hysteroscopy","volume":"125","author":"Yu","year":"2019","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.3390\/diagnostics15101234","article-title":"The incidence of adverse events in adults undergoing procedural sedation with Propofol administered by non-anesthetists: a systematic review and Meta-analysis","volume":"15","author":"Pig\u00f2","year":"2025","journal-title":"Diagnostics"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12871-024-02479-9","article-title":"Efficacy and safety of ciprofol versus propofol for anesthesia induction in adult patients received elective surgeries: a meta-analysis","volume":"24","author":"Ainiwaer","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12871-025-03217-5","article-title":"The median effective dose (ED50) and the 95% effective dose (ED95) of alfentanil in inhibiting responses to cervical dilation when combined with ciprofol during hysteroscopic procedure: a prospective, double-blind, dose-finding clinical study","volume":"25","author":"Gao","year":"2025","journal-title":"BMC Anesthesiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1080\/13697137.2020.1784870","article-title":"Removal of 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Anesthesiol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.26355\/eurrev_202207_29292","article-title":"Effect of ciprofol on induction and maintenance of general anesthesia in patients undergoing kidney transplantation","volume":"26","author":"Qin","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/s12871-025-03079-x","article-title":"Efficacy and safety of ciprofol versus propofol for anesthesia in patients undergoing gastrointestinal endoscope: a systematic review and meta-analysis of randomized controlled trials (RCT)","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Anesthesiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1186\/s12871-024-02721-4","article-title":"The efficacy of ciprofol versus propofol on anesthesia in patients undergoing endoscopy: a systematic review and meta-analysis of randomized controlled 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Ciprofol compared with Propofol during general anesthesia induction: a systematic review and meta-analysis of randomized controlled trials (RCT)","volume":"94","author":"Akhtar","year":"2024","journal-title":"J Clin Anesth"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1720728","DOI":"10.3389\/fmed.2025.1720728","article-title":"Study on the effective dose of alfentanil combined with ciprofol in inhibiting intraoperative body movement responses in patients undergoing breast lump resection","volume":"12","author":"Li","year":"2026","journal-title":"Front Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1186\/s12871-024-02787-0","article-title":"The efficacy and safety of ciprofol versus propofol in patients undergoing painless hysteroscopy: a randomized, double-blind, controlled trial","volume":"24","author":"Li","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12871-023-02387-4","article-title":"Effective doses of ciprofol combined with alfentanil in inhibiting responses to gastroscope insertion, a prospective, single-arm, single-center study","volume":"24","author":"Wu","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"590465","DOI":"10.3389\/fmed.2021.590465","article-title":"Intravenous dexmedetomidine administration prior anesthesia induction with propofol at 4\u00b0C attenuates propofol injection pain: a double-blind, randomized, placebo-controlled trial","volume":"8","author":"Lu","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/03007995.2025.2487102","article-title":"Safety and efficacy analysis of ciprofol combined with low-dose alfentanil in sedation of patients during transesophageal echocardiography: a randomized double-blind controlled study","volume":"41","author":"Jiang","year":"2025","journal-title":"Curr Med Res Opin"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1829147\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:36:33Z","timestamp":1777354593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1829147\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":27,"alternative-id":["10.3389\/fmed.2026.1829147"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1829147","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"article-number":"1829147"}}