{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:14:41Z","timestamp":1780398881648,"version":"3.54.1"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>The frequent co-occurrence of dry eye disease (DED) and depressive disorder imposes a significant dual burden on patient quality of life and healthcare systems. Current fragmented, discipline-specific care models remain inadequate for addressing this clinical reality. The core challenge lies in the absence of integrated management frameworks for comorbid presentations, with particular neglect of treatment sequencing that often compromises therapeutic outcomes. This perspective article proposes that effective management of DED-depression comorbidity should build upon shared pathophysiological mechanisms\u2014including neurogenic inflammation and eye-brain axis dysfunction\u2014to construct an integrated mind\u2013body therapeutic paradigm. We present a comprehensive framework encompassing stratified phenotypic assessment, a stepwise therapeutic ladder, and a dynamic temporal optimization strategy guided by bidirectional biological and psychological interactions. This integrated paradigm holds promise for transcending disciplinary boundaries, enabling precision treatment selection, and ultimately improving long-term patient outcomes through holistic, patient-centered care.<\/jats:p>","DOI":"10.3389\/fmed.2026.1829273","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:37:45Z","timestamp":1780396665000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated management of dry eye\u2013depression comorbidity: mechanistic insights and temporal therapeutic strategies"],"prefix":"10.3389","volume":"13","author":[{"given":"Te-du","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Comprehensive Ophthalmology, Shenzhen Shendong Aier Eye Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-long","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Ophthalmology, Shenzhen Shendong Aier Eye Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Ophthalmology, Shenzhen Shendong Aier Eye Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-rong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Special Examinations, Shenzhen Shendong Aier Eye Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Ophthalmology, Shenzhen Shendong Aier Eye Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1038\/eye.2016.186","article-title":"Depression and anxiety in dry eye disease: a systematic review and meta-analysis","volume":"30","author":"Wan","year":"2016","journal-title":"Eye"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.ajo.2014.11.028","article-title":"The association between dry eye disease and depression and anxiety in a large population-based study","volume":"159","author":"van der Vaart","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jare.2024.03.015","article-title":"Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian 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