{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:23:13Z","timestamp":1782476593219,"version":"3.54.5"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thoracic epidural analgesia is widely used for postoperative pain control and is generally considered safe. Rare but serious cardiovascular complications related to neuraxial sympathetic blockade have been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We describe a postoperative intensive care unit patient who developed transient complete heart block during early ambulation while receiving a continuous thoracic epidural bupivacaine infusion. Telemetry demonstrated abrupt progression from sinus rhythm to high-grade atrioventricular block with ventricular standstill lasting approximately seven seconds, coinciding with hypotension and vagal symptoms. The episode resolved promptly with supportive care and interruption of the epidural infusion. No recurrent arrhythmias occurred after resumption of analgesia at a lower bupivacaine concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights a rare but clinically significant complication of thoracic epidural bupivacaine infusion and underscores how local anesthetic effects, in combination with postoperative autonomic imbalance, may precipitate transient high-grade atrioventricular block.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1829484","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:35:17Z","timestamp":1778736917000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transient complete heart block during early ambulation associated with thoracic epidural bupivacaine infusion in the intensive care unit: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Harshkumar B.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Clinical Center, National Institutes of Health","place":["Bethesda, MD, United States"]},{"name":"Critical Care Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Ho","sequence":"additional","affiliation":[{"name":"Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Blakely","sequence":"additional","affiliation":[{"name":"Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Chertow","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Clinical Center, National Institutes of Health","place":["Bethesda, MD, United States"]},{"name":"Critical Care Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health","place":["Bethesda, MD, United States"]},{"name":"Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health","place":["Hamilton, MT, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1016\/j.ejso.2020.07.041","article-title":"Guidelines for perioperative care in cytoreductive surgery (CRS) with or without hyperthermic intraPEritoneal chemotherapy (HIPEC): enhanced recovery after 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