{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:09:06Z","timestamp":1788930546896,"version":"build-2803163510"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glaucoma secondary to neurofibromatosis type 1 (NF1) is a vision-threatening complication characterized by variable phenotypic expression. The prognostic significance of specific anterior segment signs, particularly ectropion uveae (EU), remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a 7-year-old girl with NF1 who presented with unilateral refractory glaucoma and prominent EU in the affected eye. Despite maximal medical therapy and sequential surgical interventions, including microcatheter-assisted transluminal trabeculotomy, subsequent scar tissue excision with goniotomy, and two sessions of transscleral cyclophotocoagulation, intraocular pressure (IOP) remained uncontrolled. Implantation of a glaucoma drainage device (GDD) resulted in initial IOP reduction, with IOP maintained at 16\/18 mmHg during the first 3 months. At 1 year post-GDD, IOP was 23 mmHg, and brinzolamide was subsequently added.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This 4-year longitudinal case highlights an association between prominent ectropion uveae and a refractory surgical course in this patient. Traditional angle surgeries appeared to carry a high risk of failure, whereas GDD implantation provided IOP reduction from 42 to 23 mmHg at 1 year, although adjunctive medication was subsequently required. This observation raises the question of whether earlier GDD implantation might prove beneficial in similar patients. However, this hypothesis requires validation in a larger series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1829841","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:43:55Z","timestamp":1788929035000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ectropion uveae in a pediatric patient with refractory NF1-associated glaucoma: a 4-year case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Yulei","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuitang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shijiazhuang People's Hospital","place":["Hebei, Shi Jia Zhuang, 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