{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:38Z","timestamp":1782103778146,"version":"3.54.5"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recurrence of diabetic foot ulcers (DFU) is a major clinical challenge, often leading to amputation. Temperature-guided preventive care based on skin temperature monitoring has been proposed as an early warning tool that can trigger preventive actions before overt ulceration develops. We conducted a systematic review and meta-analysis to evaluate its efficacy in preventing DFU recurrence in high-risk individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, the Wiley Online Library, and Web of Science for randomized controlled trials comparing temperature-guided preventive care based on skin temperature monitoring with standard care. The primary outcome was time to first ulcer recurrence, with the hazard ratio (HR) as the effect measure. The secondary outcome was overall recurrence incidence, measured by the risk ratio (RR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six randomized controlled trials involving a total of 917 participants were included. The meta-analysis demonstrated a significant protective effect for temperature-guided preventive care. The intervention group had a significantly lower hazard of ulcer recurrence compared with the control group (HR 0.63; 95% CI: 0.49\u20130.82;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). Similarly, the overall risk of recurrence was significantly reduced in the intervention group (RR 0.64; 95% CI: 0.52\u20130.80;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Temperature-guided preventive care appears to be an effective, patient-driven intervention that may reduce the risk and incidence of DFU recurrence in high-risk individuals. These findings support the potential integration of this simple, proactive tool into standard preventive care protocols to mitigate the severe consequences of this complication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1830535","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:36:23Z","timestamp":1782102983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy of temperature-guided preventive care in reducing diabetic foot ulcer incidence and prolonging ulcer-free survival: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.3389","volume":"13","author":[{"given":"Sheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery, West China Hospital of Sichuan University-Ziyang Hospital, Ziyang Central Hospital, Ziyang","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, West China Hospital of Sichuan University-Ziyang Hospital, Ziyang Central Hospital, Ziyang","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, West China Hospital of Sichuan University-Ziyang Hospital, Ziyang Central Hospital, Ziyang","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zuo","sequence":"additional","affiliation":[{"name":"Clinical Medical College and Affiliated Hospital of North Sichuan Medical College, Nanchong","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"402","author":"GBD","year":"2023","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S252","DOI":"10.2337\/dc25-S012","article-title":"12. 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