{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:59:49Z","timestamp":1787162389518,"version":"build-2736575974"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Science and Technology Project of Hebei Province Health Industry","award":["20210947"],"award-info":[{"award-number":["20210947"]}]},{"name":"Key Scientific and Technological Research Program of the Health Industry Project of Hebei Province","award":["20241447"],"award-info":[{"award-number":["20241447"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Femoral hernias are relatively uncommon in clinical practice but are of considerable clinical significance because they are associated with a higher risk of strangulation happening. Even rarer is the discovery of the appendix within the hernia sac, a condition known as De Garengeot hernia, and within this already highly unlikely scenario, having a tumor within the hernia is exceedingly rare. Among such cases, Goblet cell carcinoma (GCC) represents an incredibly rare occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We present the case of an 83-year-old man who had undergone transabdominal preperitoneal (TAPP) repair for an incarcerated femoral hernia. During the operation, the incarcerated part was found to be the tip of the appendix, which made it necessary to perform a laparoscopic appendectomy (LA). Subsequent histopathological examination revealed GCC invading the muscularis propria, and given the patient\u2019s advanced age, significant comorbidities, and the family\u2019s stated preference, a right hemicolectomy was not performed. At the 1-year follow-up, computed tomography (CT) and tumor markers indicated no sign of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For older individuals with co-existing health conditions and those at the early stage of GCC, a cautious management approach backed by active monitoring might be a sensible option following a thorough evaluation of risks and benefits, and this instance provides a realistic view on dealing with such rare and medically complex scenarios.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1831458","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:48:14Z","timestamp":1780462094000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Incarcerated femoral hernia of the appendix with incidental discovery of goblet cell carcinoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Lifei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunna","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e56636","DOI":"10.7759\/cureus.56636","article-title":"Inguinoscrotal hernia of the urinary bladder","volume":"16","author":"Sripathi","year":"2024","journal-title":"Cureus"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e0323790","DOI":"10.1371\/journal.pone.0323790","article-title":"Global burden and future trends of inguinal, femoral, and abdominal hernia in older adults: a systematic analysis from the global burden of disease study 2021","volume":"20","author":"Zhang","year":"2025","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/5324320","article-title":"A rare case of chronic appendicitis superimposed on an incarcerated de Garengeot hernia prospectively identified on computed tomography","volume":"2018","author":"Goldbach","year":"2018","journal-title":"Case Rep Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.5811\/cpcem.35386","article-title":"De Garengeot Hernia with Acute Gangrenous Appendicitis Case 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appendectomy","volume":"16","author":"Chiba","year":"2024","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4103\/0971-9261.93978","article-title":"Amyand's hernia","volume":"17","author":"Yagnik","year":"2012","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3872","DOI":"10.3390\/cancers15153872","article-title":"The vermiform appendix and its pathologies","volume":"15","author":"Constantin","year":"2023","journal-title":"Cancers (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1053\/j.semdp.2024.08.003","article-title":"Goblet cell adenocarcinoma","volume":"41","author":"Veerapong","year":"2024","journal-title":"Semin Diagn Pathol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1831458\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:48:41Z","timestamp":1780462121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1831458\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":10,"alternative-id":["10.3389\/fmed.2026.1831458"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1831458","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"article-number":"1831458"}}