{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:08:45Z","timestamp":1784218125447,"version":"3.55.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background and study aims<\/jats:title>\n                    <jats:p>\n                      Map-like redness (MLR) is a characteristic feature of gastritis after\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) eradication and independent risk factor of gastric cancer after\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication. The present study investigated the endoscopic manifestations and histopathological features of MLR to further investigate the relationship between MLR and gastric cancer after\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We enrolled 56 consecutive MLR patients between January 2023 and July 2023. Endoscopic signs and histopathological characteristics were compared among the reddish area, transition zone, and background mucosa (areas R, T, and B, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The histopathological analysis showed significantly greater atrophy, gastric intestinal metaplasia (GIM), and dysplasia in area R compared to other areas (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Incomplete GIM predominated in area R, while complete GIM predominated in areas T and B. Area R had a higher microvascular density compared to areas T and B. Intervening parts width for area T was greater than that for area B, which was greater than that for area R (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Crypt opening sizes in area R were greater than those in area T, which were greater than those in area B (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Gastric MLR, particularly the central reddish area, was associated with localized high-risk mucosal changes, including advanced atrophy, GIM, incomplete GIM, increased microvessel density, and dysplasia in some cases. MLR may serve as an endoscopic marker of high-risk mucosal changes after successful\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1833606","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:50:00Z","timestamp":1783360200000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological features of gastric map-like redness under image-enhanced endoscopy"],"prefix":"10.3389","volume":"13","author":[{"given":"Yixiang","family":"You","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, Zhangzhou Affiliated Hospital of Fujian Medical University","place":["Zhangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wulian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shentong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanpo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Gastroenterology, 900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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