{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:38:09Z","timestamp":1793036289049,"version":"4.5.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Objective<\/jats:title>\n Multiple organ dysfunction syndrome (MODS) is a life-threatening complication of wasp stings. This study aimed to identify factors associated with MODS and develop a quantitative risk prediction model.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective cohort study included 324 wasp sting patients (January 2018\u2013December 2023), divided into MODS (\n n<\/jats:italic>\n = 90) and non-MODS (\n n<\/jats:italic>\n = 234) groups. General characteristics, imaging findings, and laboratory parameters were compared. Composite indicators with clinical interpretability were incorporated into binary logistic regression to identify risk factors. A nomogram-based prediction model was established and evaluated using ROC curves, calibration curves, and decision curves.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant differences were observed between groups in age, time from sting to admission, pleural effusion, RALE score, PLT, LYM, MO, FIB, ALB, MPV\/PLT, P-LCR, FAR, FPR, CLR, SHR, NLR, PLR, PNR, SIRI, and SII (all\n P<\/jats:italic>\n &lt; 0.05). After excluding collinear variables (VIF &gt; 5), binary logistic regression identified age, time to admission, pleural effusion, RALE score, MPV\/PLT, and SIRI as independent risk factors (OR &gt; 1, all\n P<\/jats:italic>\n &lt; 0.05). A nomogram prediction model was developed. ROC analysis showed an AUC of 0.828 (95% CI: 0.776\u20130.880). At the optimal cutoff of 0.368, sensitivity was 66.7%, specificity 87.9%, PPV 68.9%, and NPV 86.8%. Calibration curves showed good agreement, and decision curves demonstrated high net clinical benefit.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MODS occurrence after wasp stings may be associated with RALE score, MPV\/PLT, and SIRI levels, while the roles of age, time to admission, and pleural effusion require further validation. The nomogram model provides a useful reference for clinical MODS risk assessment but lacks external validation, requiring confirmation in future large-scale, multicenter, prospective studies.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1834165","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:31:20Z","timestamp":1782365480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction model for risk of multiple organ dysfunction syndrome in wasp sting patients: development and validation"],"prefix":"10.3389","volume":"13","author":[{"given":"Hongmei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hematology, Yunyang County People\u2019s Hospital, Yunyang County","place":["Chongqing, China"]},{"name":"Health Management Center, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hematology, Yunyang County People\u2019s Hospital, Yunyang County","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hematology, Yunyang County People\u2019s Hospital, Yunyang County","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hematology, Yunyang County People\u2019s Hospital, Yunyang County","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Du","sequence":"additional","affiliation":[{"name":"Health Management Center, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Metabolism and Immunology Laboratory for Urological Diseases, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1159\/000542248","article-title":"Characteristics of patients with anaphylaxis to European Hornet (Vespa crabro) venom compared to anaphylaxis to wasp (Vespula spp.) venom in Southern Germany.","volume":"186","author":"Bertlich","year":"2025","journal-title":"Int Arch Allergy Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jaip.2025.09.038","article-title":"Omalizumab enables bee venom desensitisation in patients with anaphylactic reactions to venom immunotherapy.","volume":"14","author":"Capper","year":"2026","journal-title":"J Allergy Clin 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