{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:01:40Z","timestamp":1784894500329,"version":"3.55.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the clinical features, diagnostic workup, and management of Epstein\u2013Barr virus (EBV)-associated retinitis in a patient without overt clinical evidence of severe immunodeficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 33-year-old Chinese man presented with a 1-month history of blurred vision, redness, and photophobia in the left eye. Ocular examination revealed vitritis, white snowball-like vitreous deposits, optic disc edema, yellow-white retinal lesions, and tortuous retinal veins. Optical coherence tomography and fluorescein angiography supported active posterior segment inflammation. Initial vitreous smear and bacterial and fungal cultures were negative. Polymerase chain reaction testing of a vitreous sample detected EBV DNA at 123 copies\/mL, whereas herpes simplex virus (HSV), varicella-zoster virus (VZV), and cytomegalovirus (CMV) were negative. The patient received systemic acyclovir combined with corticosteroid therapy. Intraocular inflammation improved markedly, but pars plana vitrectomy was later performed because of persistent organized vitreous opacity and retinal traction. At the 4-month follow-up, retinal lesions had largely resolved and best-corrected visual acuity improved to 0.2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that EBV should be considered in the differential diagnosis of atypical infectious retinitis. Vitreous PCR may provide important etiological evidence, and timely combined medical and surgical management may contribute to a favorable outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1835638","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:10:21Z","timestamp":1784891421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epstein\u2013Barr virus-associated retinitis: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Weiwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]},{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1016\/j.cell.2022.08.026","article-title":"Epstein-Barr virus: biology and clinical disease.","volume":"185","author":"Damania","year":"2022","journal-title":"Cell."},{"key":"B2","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/ICB.0000000000000508","article-title":"Retinal vasculitis associated with Epstein-Barr virus infection, a case report.","volume":"12","author":"Victor","year":"2018","journal-title":"Retin Cases Brief Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2147\/IMCRJ.S107089","article-title":"A case report of Epstein-Barr virus-associated retinal vasculitis: successful treatment using only acyclovir therapy.","volume":"9","author":"Keorochana","year":"2016","journal-title":"Int Med Case Rep J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e11663","DOI":"10.1097\/MD.0000000000011663","article-title":"Retinitis associated with double infection of Epstein-Barr virus and varicella-zoster virus: a case report.","volume":"97","author":"Sato","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"990240","DOI":"10.3389\/fopht.2022.990240","article-title":"Advances in the microbiological diagnosis of herpetic retinitis.","volume":"2","author":"Gueudry","year":"2022","journal-title":"Front Ophthalmol (Lausanne)."},{"key":"B6","doi-asserted-by":"publisher","first-page":"916113","DOI":"10.3389\/fopht.2022.916113","article-title":"Acute retinal necrosis: a mini review.","volume":"2","author":"Hoogewoud","year":"2022","journal-title":"Front Ophthalmol (Lausanne)."},{"key":"B7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40942-023-00465-w","article-title":"Polymerase chain reaction test for diagnosis of infectious uveitis.","volume":"9","author":"Fekri","year":"2023","journal-title":"Int J Retina Vitreous."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1038\/s41433-024-03028-x","article-title":"Diagnostic and therapeutic challenges in acute retinal necrosis; 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