{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:03:35Z","timestamp":1784203415755,"version":"3.55.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Clopidogrel is widely used after structural heart interventions, but symptomatic intraocular pressure (IOP) abnormalities without clinically evident hemorrhage are rarely reported. We describe a 52-year-old woman who developed recurrent ocular discomfort, eye pain, and blurred vision after percutaneous patent foramen ovale closure followed by clopidogrel-containing antiplatelet therapy. Baseline pre-exposure assessment showed ocular hypertension with angle crowding features but no definite glaucomatous structural or functional damage. Symptoms improved after clopidogrel withdrawal and recurred after re-administration. During recurrent symptomatic exposure, 24-h IOP monitoring showed marked peak elevation and diurnal fluctuation in both eyes. Baseline pre-exposure IOP measurements were available, but baseline 24-h IOP monitoring was not performed; therefore, worsening relative to the patient's baseline diurnal pattern could not be confirmed. Formal gonioscopy and symptomatic-phase angle reassessment were unavailable, and intermittent angle closure could not be excluded. This case represents a dechallenge\u2013rechallenge-supported temporal association and hypothesis-generating pharmacovigilance signal rather than definitive evidence of a clopidogrel-induced effect.<\/jats:p>","DOI":"10.3389\/fmed.2026.1836893","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:10:19Z","timestamp":1784200219000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptomatic intraocular pressure dysregulation during clopidogrel exposure after patent foramen ovale closure in a patient with ocular hypertension and angle crowding: a Case Report"],"prefix":"10.3389","volume":"13","author":[{"given":"Faxue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital","place":["Lanzhou, Gansu, 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