{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:59:47Z","timestamp":1780898387070,"version":"3.54.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Hafnia alvei<\/jats:italic>\n                      (\n                      <jats:italic>H. alvei<\/jats:italic>\n                      ) is an opportunistic pathogen that rarely causes extraintestinal infections. Chorioamnionitis involving this bacterium, though uncommon, can be life-threatening and rapidly progress to maternal septic shock. However, in the setting of polymicrobial infection\u2014particularly when co-existing with\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      , a well-recognized pathogen in obstetric sepsis\u2014the severe clinical manifestations cannot be attributed solely to\n                      <jats:italic>H. alvei<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>\n                      We report a case of a 27-year-old primipara at 33\u202f+\u202f5\u202fweeks of gestation presenting with low-grade fever, lower abdominal pain, and tachycardia. Given high suspicion of intrauterine infection, a multidisciplinary consultation was conducted prior to delivery. The obstetric team diagnosed chorioamnionitis with risks of maternal septic shock and fetal distress. An emergency cesarean section was performed, during which placental surface swab and aerobic and anaerobic blood cultures were collected, followed by initiation of broad-spectrum antimicrobial therapy. Postoperatively, the patient\u2019s condition deteriorated, requiring intensive care and norepinephrine administration to maintain hemodynamic stability. Empirical treatment with meropenem was administered to control infection. The preterm infants suffered from severe infections and survived after 3\u202fweeks of treatment. Blood cultures obtained postoperatively revealed a rare mixed infection of\n                      <jats:italic>H. alvei<\/jats:italic>\n                      and\n                      <jats:italic>E. coli<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case suggests that although\n                      <jats:italic>H. alvei<\/jats:italic>\n                      is relatively rare in extraintestinal infections, it may become an important pathogen in obstetrics. The rapid progression of the patient\u2019s condition and the lack of definitive treatment guidelines underscore the importance of early clinical recognition and the use of appropriate empirical antibiotic therapy based on local antimicrobial susceptibility patterns. This report supplements the literature on\n                      <jats:italic>H. alvei<\/jats:italic>\n                      infection during pregnancy and confirms the critical role of blood cultures in guiding targeted treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1840743","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:33:41Z","timestamp":1780896821000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hafnia alvei infection complicated by chorioamnionitis and septicemia: a case report and review of literature"],"prefix":"10.3389","volume":"13","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Shijiazhuang Obstetrics and Gynecology Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shijiazhuang Obstetrics and Gynecology Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shijiazhuang Obstetrics and Gynecology Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad500.665","article-title":"598. 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