{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:48:11Z","timestamp":1785829691892,"version":"3.56.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Plexiform neurofibroma (PN) is extremely rare in the perianal region, primarily attributed to the lack of thick nerve trunks in the perianal area, and is closely related to neurofibromatosis type 1 (\n                      <jats:italic>NF1<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>Here we described a 21-year-old man who was admitted to the hospital with a chief complaint of a painless mass on the left perianal area for 10\u202fyears. Physical examination revealed a nodular cystic-solid mass approximately 6.0\u202fcm\u202f\u00d7\u202f3.0\u202fcm in size in the left perianal area, with an irregular shape, soft texture, good mobility, and no obvious tenderness; no abnormalities were found during rectal examination. Preoperative pelvic magnetic resonance imaging revealed a 55\u202f\u00d7\u202f27\u202fmm soft tissue lesion in the left ischial region, with radiological characteristics typical of nerve-derived tumors. The patient underwent complete surgical resection of the tumor, and postoperative histopathological analysis confirmed the diagnosis of PN without malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Complete surgical resection was the cornerstone, and histopathological confirmation was crucial. Long-term surveillance should be regarded as a means to prevent tumor recurrence or metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1842411","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:30:07Z","timestamp":1785425407000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative pathology confirmed perianal plexiform neurofibroma: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhong Bo","family":"Wu","sequence":"first","affiliation":[{"name":"Brain Disease Research Center, Tongren Municipal People\u2019s Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Tongren Municipal People\u2019s Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Tongren Municipal People\u2019s Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru Song","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Tongren Municipal People\u2019s Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Tongren Municipal People\u2019s Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Tongren Municipal People\u2019s Hospital","place":["Tongren, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1097\/DAD.0000000000002322","article-title":"Isolated, nonsyndromic Mucocutaneous plexiform Neurofibromas: a systematic review of the clinicopathologic features","volume":"44","author":"Jonathan","year":"2022","journal-title":"Am J Dermatopathol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.gim.2022.05.013","article-title":"Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation","volume":"23","author":"Eric","year":"2021","journal-title":"Genet Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00401-024-02724-y","article-title":"Histologic correlates of \u201cchoroidal abnormalities\u201d in Neurofibromatosis type 1 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