{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:37:43Z","timestamp":1782895063390,"version":"3.54.5"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the molecular profile of adult patients with Scalp psoriasis (SP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed 92 inflammatory biomarkers in lesional scalp skin from SP patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f20) and demographically comparable healthy controls (HCs,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f12) using Olink high-throughput proteomics, and investigated the expression of Th2-type cytokines using ELISA in an independent cohort (contains 11 SP patients and 5 HCs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 28 differentially expressed proteins (DEPs) in lesional SP compared to HCs (FC \u2265 \u00b11.2, adjusted\n                      <jats:italic>p<\/jats:italic>\n                      -value &amp;lt;0.05). We observed that SP exhibits a Th1\/Th17\/IL-12\/IL-23-dominant molecular signature. GO clustering and KEGG pathway analyses demonstrated close interrelationships among cytokines, chemokines, and their receptors during the psoriatic inflammatory cascade. Moreover, our results indicated a down-regulation of Th2-type molecules in the SP group, evidenced by significantly reduced levels of IL-4 and IL-5. Notably, these decreases were negatively correlated with the scalp-specific Investigator\u2019s Global Assessment (ss-IGA) scores (IL-4:\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f\u22120.78,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.01; IL-5:\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f\u22120.65,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.05), which may lead to an imbalance characterized by an enhanced Th1\/Th17\/IL-12\/IL-23 inflammatory response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This proteomic profile provides a new perspective on the immunological pathogenesis of SP, suggesting an imbalance between Th2 and Th1\/Th17\/IL-12\/IL-23 responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1842465","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:07:26Z","timestamp":1782889646000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reanalysis of the immunological characteristics of scalp psoriasis: a cross-sectional study using Olink proteomics"],"prefix":"10.3389","volume":"13","author":[{"given":"Liping","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Dermatology Hospital of Zhejiang Province","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dermatology Hospital of Zhejiang Province","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dermatology Hospital of Zhejiang Province","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dermatology Hospital of Zhejiang Province","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling 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