{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:29:03Z","timestamp":1787149743177,"version":"build-2736575974"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with Myalgic Encephalomyelitis (ME)\/Chronic Fatigue Syndrome (CFS) experience significant sensory problems that affect their personal, social and occupational life. However, there is no clear understanding of how the sensory problems manifest in ME\/CFS. Neuroimaging studies have provided indirect evidence of the involvement of sensory brain areas in ME\/CFS. This novel systematically examined the role of early sensory processing and late information processing brain systems in ME\/CFS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The participants consisted of 31 ME\/CFS patients and 30 healthy matched controls. Measures of subjective experience of sensory problems as well as event-related brain potentials (ERPs) on an auditory paired click task and an auditory oddball task were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ME\/CFS patients reported significantly higher sensory problems compared to the control group. On the ERP measures, the ME\/CFS group was not significantly different on the P50 suppression index than the control group. However, the ME\/CFS group showed a significantly reduced P300 potential compared with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that the higher-order control-based brain mechanism contributes to the sensory problems experienced by ME\/CFS patients. These findings could have profound implications for targeted interventions directed towards higher-order brain systems, rather than the sensory systems, to address challenges related to sensory processing problems in ME\/CFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1842841","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:38:08Z","timestamp":1781757488000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Higher-order brain processes, rather than early processing, underlie sensory problems in ME\/CFS: evidence from ERPs"],"prefix":"10.3389","volume":"13","author":[{"given":"Sanjay","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Psychology, Social Work and Public Health, Oxford Brookes University","place":["Oxford, United 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