{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:51:25Z","timestamp":1793814685331,"version":"4.6.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this study was to compare the effectiveness of amniotic membrane plugging (AMP) versus acellular porcine corneal stroma (APCS) partially penetrating deep anterior lamellar keratoplasty (PP-DALK) in the treatment of small corneal perforation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 44 patients (44 eyes) with small corneal perforation (&amp;lt;3\u202fmm in diameter) were retrospectively included. Among them, 24 eyes were treated with AMP (AMP group), and 20 eyes were treated with APCS-PP-DALK (APCS-PP-DALK group). The best-corrected visual acuity (BCVA), corneal transparency, ocular irritation symptoms, corneal thickness, primary disease control, postoperative complications, and survival rate were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups showed significant postoperative improvement in BCVA versus baseline (both\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), with no difference in overall visual outcome between APCS-PP-DALK and AMP groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.607). Corneal transparency was better in the APCS-PP-DALK group at 1, 3, and 6\u202fmonths compared with the AMP group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05), though this difference resolved by 12\u202fmonths. Corneal thickness increased significantly in both groups after surgery, with the APCS-PP-DALK group exhibiting greater thickness than the AMP group at 6\u202fmonths (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). The primary disease control rate was 85% in the APCS-PP-DALK group and 87.5% in the AMP group, yielding no statistically significant difference between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.810). Furthermore, the incidence of postoperative complications was comparable between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.844).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both AMP and APCS-PP-DALK are effective and safe treatments for small corneal perforation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1845722","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:38:23Z","timestamp":1779251903000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Amniotic membrane plugging versus acellular porcine corneal partially penetrating deep anterior lamellar keratoplasty in the treatment of small corneal perforation"],"prefix":"10.3389","volume":"13","author":[{"given":"Yingxin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ba","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.survophthal.2011.06.003","article-title":"Management of corneal 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therapeutic Keratoplasty","volume":"27","author":"Li","year":"2020","journal-title":"Xenotransplantation"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1534210","DOI":"10.3389\/fmed.2025.1534210","article-title":"Lamellar Keratoplasty using acellular porcine corneal stroma for the treatment of corneal ulcers","volume":"12","author":"Hu","year":"2025","journal-title":"Front Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"121745","DOI":"10.1016\/j.biomaterials.2022.121745","article-title":"Reconstructing auto tissue engineering lamellar cornea with aspartic acid modified acellular porcine corneal stroma and preconditioned Limbal stem cell for corneal regeneration","volume":"289","author":"Wang","year":"2022","journal-title":"Biomaterials"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"123156","DOI":"10.1155\/2014\/123156","article-title":"Descemetic and Predescemetic Dalk in Keratoconus patients: a clinical and confocal perspective 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Appl"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13287-021-02684-0","article-title":"Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge","volume":"13","author":"Elkhenany","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"571757","DOI":"10.2147\/opth.S571757","article-title":"Sutureless amniotic membrane grafting in the management of corneal perforations associated with severe ocular surface disease","volume":"20","author":"Mancini","year":"2026","journal-title":"Clin Ophthalmol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/2008-322x.180712","article-title":"Long-term outcomes of amniotic membrane transplantation in contact Lens-induced Pseudomonas keratitis with impending corneal perforation","volume":"11","author":"Mohammadpour","year":"2016","journal-title":"J Ophthalmic Vis 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