{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:37:40Z","timestamp":1793407060509,"version":"4.5.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sino-European Center of Biomedicine and Health"},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202211020"],"award-info":[{"award-number":["SZSM202211020"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Key Laboratory of Metabolic Health","award":["ZDSYS20210427152400001"],"award-info":[{"award-number":["ZDSYS20210427152400001"]}]},{"name":"Shenzhen Science and Technology Program"},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024A1515010059"],"award-info":[{"award-number":["2024A1515010059"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Medical Research Fund","award":["B2404004"],"award-info":[{"award-number":["B2404004"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFC2707500"],"award-info":[{"award-number":["2024YFC2707500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFA1803001"],"award-info":[{"award-number":["2024YFA1803001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ovarian endometrioma (OEM) is a common manifestation of endometriosis and is associated with both local lesions and systemic alterations. While immune dysregulation and metabolic disturbances have been individually reported in endometriosis, whether these changes are coordinated at the circulating molecular level in OEM remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an exploratory integrative analysis of serum proteomic and untargeted metabolomic profiles in women with OEM and healthy controls. Differential analyses were conducted for each omics layer, followed by cross-omics integration to assess pathway-level relationships between molecular alterations. Selected platelet-associated proteins were further evaluated by enzyme-linked immunosorbent assay (ELISA) in a small independent cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum proteomics profiling showed predominant alterations in immune-related and extracellular processes, whereas metabolomic analysis revealed changes mainly involving lipid metabolism, amino acid metabolism, and redox-related pathways. Cross-omics integration suggested pathway-level correspondence between the two omics layers, particularly in carbohydrate metabolism, nucleotide metabolism, lipid remodeling, and antioxidant defense. Among platelet-associated proteins, pro-platelet basic protein (PPBP\/CXCL7) showed higher levels in OEM in both proteomic profiling and ELISA validation, while MMRN1 and PDGFA showed concordant but non-significant increases in the ELISA cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that OEM is associated with concurrent immune-related and metabolic alterations detectable in the circulation. Integrative multi-omics analysis provides exploratory evidence for pathway-level correspondence between proteomic and metabolomic alterations in OEM and provides limited independent support for a platelet-associated circulating signal, with PPBP showing the most consistent validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1846827","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:55:54Z","timestamp":1784699754000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative serum proteomic and metabolomic profiling in ovarian endometrioma: an exploratory multi-omics study"],"prefix":"10.3389","volume":"13","author":[{"given":"Na","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]},{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]},{"name":"Shenzhen School of Clinical Medicine, Southern Medical University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxia","family":"Xiao","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian V.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, Guangdong, China"]},{"name":"Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, Guangdong, China"]},{"name":"Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology","place":["Shenzhen, Guangdong, China"]},{"name":"Sino-European Center of Biomedicine and Health","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University","place":["Shenzhen, Guangdong, China"]},{"name":"Shenzhen School of Clinical Medicine, Southern Medical University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1001\/jama.2025.2975","article-title":"Endometriosis: a review","volume":"334","author":"As-Sanie","year":"2025","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-pathmechdis-012419-032654","article-title":"The origin and pathogenesis of endometriosis","volume":"15","author":"Wang","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel 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