{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:00:39Z","timestamp":1780639239848,"version":"3.54.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the clinical diagnostic features, molecular basis, and comprehensive treatment strategies for a case of follicular thyroid carcinoma (FTC) with hepatic and pulmonary metastases that developed 8 years after surgery for a Follicular Tumor of Uncertain Malignant Potential (FT-UMP), and to provide a basis for long-term follow-up and individualized treatment of such borderline tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>FTC is the second most common subtype of differentiated thyroid cancer. Currently, the diagnosis and management of distant FTC metastases remain a critical challenge, particularly when they occur in rare locations, such as the liver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      This article reports the case of a 56-year-old male patient. Within 8 years after the resection of the well-differentiated follicular neoplasm of FT-UMP, a single mass in the lateral lobe of the left liver and multiple nodules in both lungs were detected in the patient. Following a multidisciplinary team (MDT) discussion, the decision was made to perform a robot-assisted hepatectomy. Pathology confirmed the diagnosis of FTC metastasis. Subsequently, we formulated a comprehensive treatment plan including total thyroidectomy, radioactive iodine (RAI) therapy with\n                      <jats:sup>131<\/jats:sup>\n                      I and endocrine treatment. Active surveillance was adopted for the lung metastases. Twelve months of follow-up showed no signs of recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights that for patients with FT-UMP, continuous monitoring is also crucial for the early detection of metastasis. In complicated cases with liver and lung metastases from FTC, MDT collaboration is essential to formulate individualized treatment plans integrating multidisciplinary expertise and multimodal therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1848111","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:08:15Z","timestamp":1780636095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidisciplinary treatment of follicular thyroid carcinoma with hepatic and pulmonary metastases: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhongyao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1507\/endocrj.EJ21-0723","article-title":"Clinical outcomes of follicular tumor of uncertain malignant potential of the thyroid: real-world data","volume":"69","author":"Ito","year":"2022","journal-title":"Endocr J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"872527","DOI":"10.3389\/fendo.2022.872527","article-title":"The role of thyroglobulin in preoperative and postoperative evaluation of patients with differentiated thyroid cancer","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1634\/theoncologist.2009-0190","article-title":"Standard and emerging therapies for metastatic differentiated thyroid cancer","volume":"15","author":"O'Neill","year":"2010","journal-title":"Oncologist"},{"key":"B4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2265.2011.04231.x","article-title":"Long-term outcomes of distant metastasis from differentiated thyroid carcinoma","volume":"76","author":"Huang","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1634\/theoncologist.2010-0405","article-title":"Follicular adenoma and carcinoma of the thyroid gland","volume":"16","author":"McHenry","year":"2011","journal-title":"Oncologist"},{"key":"B6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.5603\/EP.a2016.0040","article-title":"Diagnosis, treatment, and prognosis in patients with liver metastases from follicular thyroid carcinoma (ftc)","volume":"67","author":"Ka\u0142u\u017cna","year":"2016","journal-title":"Endokrynol Pol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s40336-025-00732-w","article-title":"From 2015 to 2025: how ATA guidelines reshape nuclear medicine practice in thyroid cancer","volume":"14","author":"Albano","year":"2026","journal-title":"Clin Transl Imaging"},{"key":"B8","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1177\/10507256251363120","article-title":"2025 American Thyroid Association management guidelines for adult patients with differentiated thyroid cancer","volume":"35","author":"Ringel","year":"2025","journal-title":"Thyroid"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e1343","DOI":"10.1210\/clinem\/dgae581","article-title":"Impact of reclassification of oncocytic and follicular thyroid carcinoma by the 2022 who classification","volume":"110","author":"Stegenga","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3390\/cancers13071625","article-title":"Site-specific metastasis and survival in papillary thyroid cancer: the importance of brain and multi-organ disease","volume":"13","author":"Toraih","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/modpathol.2010.112","article-title":"Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns","volume":"23","author":"Rivera","year":"2010","journal-title":"Mod Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1038\/s41467-025-58910-3","article-title":"Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers","volume":"16","author":"Pan","year":"2025","journal-title":"Nat Commun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5604\/01.3001.0012.7391","article-title":"Resection of liver metastases from differentiated thyroid cancer: who might benefit? A report of 2 cases with review of literature","volume":"91","author":"Ligocka","year":"2018","journal-title":"Polski Przeglad Chirurgiczny"},{"key":"B14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12029-018-00196-4","article-title":"Long-term outcomes after hepatic and pancreatic resections for metastases from thyroid cancer: a systematic review of the literature","volume":"50","author":"Paspala","year":"2019","journal-title":"J Gastrointest Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ijscr.2014.11.080","article-title":"Solitary liver metastasis from follicular variant papillary thyroid carcinoma: a case report and literature review","author":"Djenic","year":"2015","journal-title":"Int J Surg Case Rep"},{"key":"B16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.amjoto.2005.05.017","article-title":"External beam radiotherapy for differentiated thyroid cancer","volume":"27","author":"Meadows","year":"2006","journal-title":"Am J Otolaryngol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"430","DOI":"10.4103\/0377-4929.42552","article-title":"Follicular thyroid carcinoma with metastasis to skin diagnosed by fine needle aspiration cytology","volume":"51","author":"Agarwal","year":"2008","journal-title":"Indian J Pathol Microbiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/ejcts\/ezx367","article-title":"Pulmonary metastasectomy for thyroid cancer as salvage therapy for radioactive iodine-refractory metastases","volume":"53","author":"Moneke","year":"2018","journal-title":"Eur J Cardio-Thorac Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1089\/thy.2017.0129","article-title":"European perspective on 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: proceedings of an interactive international symposium","volume":"29","author":"Luster","year":"2019","journal-title":"Thyroid"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/jc.2005-2838","article-title":"Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy","volume":"91","author":"Durante","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.62347\/THJB4749","article-title":"Effects of (131)I and TSH suppression therapy on METTL3, METTL14 levels and recurrence in thyroid cancer","volume":"15","author":"Yang","year":"2025","journal-title":"Am J Cancer Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.3390\/cancers14061470","article-title":"Is maintaining thyroid-stimulating hormone effective in patients undergoing thyroid lobectomy for low-risk differentiated thyroid cancer? A systematic review and meta-analysis","volume":"14","author":"Won","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s12020-019-02051-3","article-title":"Thyroid hormone therapy in differentiated thyroid cancer","volume":"66","author":"Grani","year":"2019","journal-title":"Endocrine"},{"key":"B24","first-page":"6108","article-title":"Serum TSH levels are associated with postoperative recurrence and lymph node metastasis of papillary thyroid carcinoma","volume":"13","author":"Xiang","year":"2021","journal-title":"Am J Transl Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"B26","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1089\/thy.2023.0711","article-title":"The effect of thyrotropin suppression on survival outcomes in patients with differentiated thyroid cancer: a systematic review and meta-analysis","volume":"34","author":"Gubbi","year":"2024","journal-title":"Thyroid"},{"key":"B27","doi-asserted-by":"publisher","first-page":"649","DOI":"10.5603\/ep.109670","article-title":"Real-world study of lenvatinib in patients with radioiodine-refractory thyroid cancer treated in a tertiary reference center","volume":"76","author":"Krajewska","year":"2025","journal-title":"Endokrynol Pol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.3390\/cancers17111800","article-title":"Systemic therapeutic options in radioiodine-refractory differentiated thyroid cancer: current indications and optimal timing","volume":"17","author":"D\u00edaz Vico","year":"2025","journal-title":"Cancers (Basel)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.20452\/pamw.4303","article-title":"Liver metastasis as the first manifestation of differentiated thyroid cancer","volume":"128","author":"Babi\u0144ska","year":"2018","journal-title":"Pol Arch Intern Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"490","DOI":"10.9738\/INTSURG-D-14-00026.1","article-title":"Differentiated thyroid cancer with liver metastases: lessons learned from managing a series of 14 patients","volume":"100","author":"Brient","year":"2015","journal-title":"Int Surg"},{"key":"B31","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1046\/j.1440-1827.2000.01065.x","article-title":"Incidentally detected liver metastasis of well-differentiated follicular carcinoma of the thyroid, mimicking ectopic thyroid","volume":"50","author":"Kondo","year":"2000","journal-title":"Pathol Int"},{"key":"B32","first-page":"44","article-title":"Hepatic metastasis of differentiated thyroid carcinoma","volume":"8","author":"Kraft","year":"2005","journal-title":"Nucl Med Rev Cent East Eur"},{"key":"B33","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1530\/EDM-20-0074","article-title":"Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread","volume":"2020","author":"Ostrovsky","year":"2020","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"B34","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s13256-016-1140-z","article-title":"Follicular thyroid carcinoma presenting as solitary liver metastasis: a case report","volume":"10","author":"Battoo","year":"2016","journal-title":"J Med Case Rep"},{"key":"B35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/00003072-199602000-00017","article-title":"Isolated liver metastases from follicular thyroid cancer","volume":"21","author":"Graves","year":"1996","journal-title":"Clin Nucl Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s00595-004-2949-4","article-title":"Liver metastasis from thyroid carcinoma 32 years after resection of the primary tumor: report of a case","volume":"35","author":"Kouso","year":"2005","journal-title":"Surg Today"},{"key":"B37","doi-asserted-by":"publisher","first-page":"652","DOI":"10.4103\/0973-1482.138003","article-title":"A case report of breast and liver metastases of thyroid follicular carcinoma","volume":"11","author":"Tanriverdi","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"B38","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1089\/thy.1996.6.607","article-title":"Metastasis to the liver in well-differentiated carcinoma of the thyroid","volume":"6","author":"Shah","year":"1996","journal-title":"Thyroid"},{"key":"B39","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s00595-004-2922-2","article-title":"Unusual metastatic spread of follicular thyroid carcinoma: report of a case","volume":"35","author":"Kelessis","year":"2005","journal-title":"Surg Today"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1848111\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:08:16Z","timestamp":1780636096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1848111\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":39,"alternative-id":["10.3389\/fmed.2026.1848111"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1848111","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"article-number":"1848111"}}