{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:47:22Z","timestamp":1782820042509,"version":"3.54.5"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Previous studies in animal models have demonstrated that mesenchymal stem cells (MSCs) are beneficial for reconstructing the ocular surface during corneal wound healing; however, clinical evidence remains scarce. This study aimed to evaluate the clinical safety, feasibility, and preliminary outcomes of subconjunctival umbilical-cord delivered-MSC (UC-MSC) injection as an adjunctive therapy for severe corneal chemical injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, single-arm clinical case series enrolled six patients with severe corneal chemical injuries. Human UC-MSCs at passages 5\u20136 were cultured and verified. A total sample of 4\u202f\u00d7\u202f10\n                      <jats:sup>6<\/jats:sup>\n                      cells suspended in 400\u202f\u03bcL of 1\u202f\u00d7\u202fHanks\u2019 Balanced Salt Solution (HBSS) were subconjunctivally delivered adjacent to the limbus using a 360\u00b0 circumferential injection technique. Concurrently, all patients underwent amniotic membrane transplantation (AMT) and received a standard 4-week topical regimen (Tobradex, recombinant human epidermal growth factor, and Solcoseryl). Clinical safety, limbal ischemia, inflammatory indices, and epithelial defect areas were assessed through a digital slit-lamp examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No localized or systemic adverse events, such as anterior uveitis, progressive ulceration, intraocular infection, or immunological rejection, were observed in any participant. By 4\u202fweeks post-injection, active ocular surface inflammation had significantly decreased in all eyes. Of the five patients with baseline limbal ischemia, four achieved complete revascularization and resolution; the fifth exhibited a marked reduction in ischemia from 100 to 20%. Furthermore, stable corneal re-epithelialization was achieved in five of six eyes, including one with complete paracentral epithelial coverage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Subconjunctival UC-MSC delivery is a safe and feasible adjunctive therapy for managing severe corneal chemical injuries. This cell-based intervention synergizes with conventional therapies to suppress acute inflammation, rescue limbal perfusion while potentially mitigating subsequent corneal neovascularization, and accelerate the structural reconstruction of the ocular surface microenvironment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1849667","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:11:42Z","timestamp":1782817902000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Subconjunctival Injection of Mesenchymal Stem Cells for Corneal Wound Healing After Chemical Injury: Impact on Epithelial Coverage, Limbal Ischemia, and Ocular Surface Inflammatory"],"prefix":"10.3389","volume":"13","author":[{"given":"Shangkun","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University","place":["Guiyang, Guizhou, China"]},{"name":"Guizhou Medical University","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","place":["Birmingham, United Kingdom"]},{"name":"China Scholarship Council","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University","place":["Guiyang, Guizhou, China"]},{"name":"Guizhou Medical University","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University","place":["Guiyang, Guizhou, China"]},{"name":"Guizhou Medical University","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University","place":["Guiyang, Guizhou, China"]},{"name":"Guizhou Medical University","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University","place":["Guiyang, Guizhou, China"]},{"name":"Guizhou Medical University","place":["Guiyang, Guizhou, China"]},{"name":"Department of Ophthalmology, Guizhou Provincial People\u2019s Hospital","place":["Guiyang, Guizhou, 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