{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:51:27Z","timestamp":1781679087578,"version":"3.54.5"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical characteristics, misdiagnosis causes, and preventive strategies of pseudo-Meigs\u2019 syndrome, and to improve clinicians\u2018 awareness of pelvic tumors presenting with pleural effusion and ascites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 45-year-old woman presented with a 2-month history of dyspnea and a large right-sided pleural effusion with markedly elevated CYFRA 21-1 (&amp;gt;500 ng\/mL). Thoracoscopic pleural biopsy showed atypical cells with positive Calretinin, leading to a pathology report of \u201csuspicious for mesothelioma.\u201d The patient was diagnosed with malignant pleural mesothelioma and received two cycles of pemetrexed plus carboplatin chemotherapy. When symptoms did not improve and ascites developed, pelvic CT revealed a 7.0 \u00d7 5.5 cm ovarian mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative pathology confirmed bilateral ovarian borderline serous cystadenoma with focal low-grade serous carcinoma\u2014pseudo-Meigs\u2018 syndrome. After tumor resection, the pleural effusion and ascites resolved completely, and the patient remained disease-free at 4-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pseudo-Meigs\u2019 syndrome can closely mimic malignant pleural mesothelioma. For any woman with unexplained pleural effusion, pelvic imaging should be performed before invasive thoracic procedures to avoid catastrophic misdiagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1849707","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:51:52Z","timestamp":1781675512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pseudo-Meigs\u2018syndrome mimicking malignant pleural mesothelioma: a case report and diagnostic pitfall analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Hongmei","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkang","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/0002-9378(54)90258-6","article-title":"Fibroma of the ovary with ascites and hydrothorax; Meigs\u2019 syndrome.","volume":"67","author":"Meigs","year":"1954","journal-title":"Am J Obstet Gynecol"},{"key":"B2","first-page":"13","article-title":"Meigs\u2019 and pseudo-Meigs\u2018 syndrome: a narrative review of the literature.","volume":"87","author":"Garg","year":"2022","journal-title":"Gynecol Obstet Invest"},{"key":"B3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.5858\/arpa.2017-0124-RA","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the international mesothelioma interest group.","volume":"142","author":"Husain","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"B4","first-page":"141","article-title":"Elevated CYFRA 21-1 in Meigs\u2019 syndrome: a case report and literature review.","volume":"57","author":"Lin","year":"2018","journal-title":"Taiwan J Obstet Gynecol"},{"key":"B5","first-page":"e123","article-title":"Markedly elevated CYFRA 21-1 in benign ovarian fibroma with Meigs\u2018 syndrome: a case report.","volume":"54","author":"Sampson","year":"2016","journal-title":"Clin Chem Lab Med"},{"key":"B6","first-page":"24","article-title":"Ovarian torsion: a spectrum of disease and its management.","volume":"17","author":"Riker","year":"2019","journal-title":"World J Surg Oncol"},{"key":"B7","first-page":"381","article-title":"The role of vascular endothelial growth factor in the pathogenesis and treatment of Meigs\u2019 syndrome.","volume":"77","author":"Abramov","year":"2002","journal-title":"Fertil Steril"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1056\/NEJMp1303712","article-title":"From mindless to mindful practice\u2013cognitive bias and clinical decision making.","volume":"368","author":"Croskerry","year":"2013","journal-title":"N Engl J Med"},{"key":"B9","first-page":"2924","article-title":"Meigs\u2018 syndrome: an update for the radiologist.","volume":"46","author":"Gubbels","year":"2021","journal-title":"Abdom Radiol (NY)"},{"key":"B10","volume-title":"TNM Classification of Malignant Tumours.","author":"Brierly","year":"2017"},{"key":"B11","first-page":"1427","article-title":"A case of pseudo-Meigs\u2019 syndrome with marked elevation of serum CA125 and CYFRA.","volume":"46","author":"Sumi","year":"2020","journal-title":"J Obstet Gynaecol Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.3390\/medicina59091684","article-title":"Meigs syndrome and elevated CA-125: case report and literature review of an unusual presentation mimicking ovarian cancer.","volume":"59","author":"Iavarone","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"B13","first-page":"215","article-title":"Misdiagnosis of pseudo-Meigs\u2018 syndrome: a systematic review of 178 cases.","volume":"40","author":"Liu","year":"2024","journal-title":"Gynecol Endocrinol"},{"key":"B14","first-page":"e70035","article-title":"Pseudo-Meigs\u2019 syndrome mimicking pleural mesothelioma: a case report and review of the literature.","volume":"13","author":"Kim","year":"2025","journal-title":"Respirol Case Rep"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1849707\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:51:54Z","timestamp":1781675514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1849707\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":14,"alternative-id":["10.3389\/fmed.2026.1849707"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1849707","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"article-number":"1849707"}}