{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:58:56Z","timestamp":1781240336804,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-traumatic gastrointestinal injuries, especially those involving the duodenum and proximal jejunum, present significant management challenges. Complications such as retroperitoneal abscess, high intestinal obstruction, and secondary pancreatitis can lead to prolonged fasting and severe nutritional deficiencies. We report a complex case where a patient developed a rare triad of post-operative combined abscess (retroperitoneal abscess and intra-abdominal abscess)-induced high intestinal obstruction, traumatic pancreatitis, and subsequent Wernicke's encephalopathy (WE), highlighting the diagnostic and therapeutic complexities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 52-year-old woman was admitted 10 days after undergoing a partial jejunectomy for a traumatic jejunal perforation. Post-admission, she developed a combined abscess (retroperitoneal abscess and intra-abdominal abscess) adjacent to the duodenum, causing high intestinal obstruction manifested by intractable nausea and vomiting. Despite conservative management and placement of a nasointestinal decompression tube, her symptoms persisted. The clinical course was further complicated by a significant elevation in serum lipase, indicating traumatic pancreatitis. Following prolonged fasting and vomiting, the patient received total parenteral nutrition (TPN) during the prolonged period of duodenal obstruction; however, the thiamine content in the TPN formulation was inadequate, contributing to the development of thiamine deficiency. The patient presented with atypical neurological symptoms, including severe dizziness, orthostatic instability, and nystagmus (horizontal and vertical). Brain MRI revealed characteristic hyperintensities in the periaqueductal gray matter, mammillary bodies, and bilateral medial thalami, confirming a diagnosis of Wernicke's encephalopathy. High-dose parenteral thiamine (vitamin B1) was promptly initiated, resulting in rapid and significant improvement in both neurological and gastrointestinal symptoms. Subsequently, the combined abscess (retroperitoneal abscess and intra-abdominal abscess) resolved, duodenal patency was confirmed by imaging, and the patient successfully transitioned to an oral diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the critical importance of a multidisciplinary approach in managing complex post-traumatic gastrointestinal sequelae. It highlights the need for a high index of suspicion for Wernicke's encephalopathy in patients with prolonged fasting, especially when neurological symptoms are atypical. Early recognition and treatment with thiamine are paramount to prevent irreversible neurological damage. Furthermore, the interplay between mechanical obstruction, inflammation (pancreatitis and abscess formation), and metabolic derangements (thiamine deficiency) created a self-perpetuating cycle of morbidity that required sequential, targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1849748","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:41:01Z","timestamp":1781239261000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: a case of prolonged post-traumatic duodenal obstruction complicated by traumatic pancreatitis and Wernicke's encephalopathy: a multidisciplinary challenge"],"prefix":"10.3389","volume":"13","author":[{"given":"Li-Bin","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Hernia and Abdominal Wall Surgery, Affiliated Hospital of Chengdu University, Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Hernia and Abdominal Wall Surgery, Affiliated Hospital of Chengdu University, Chengdu","place":["Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Hernia and Abdominal Wall Surgery, Affiliated Hospital of Chengdu University, Chengdu","place":["Sichuan, 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