{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:53:07Z","timestamp":1781844787079,"version":"3.54.5"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Bronchogenic cysts are rare congenital foregut malformations that most commonly occur in the thoracic cavity, whereas involvement of the gastric cardia is exceptionally uncommon. We report the case of a 36-year-old man who presented with abdominal distension and was found to have a cystic lesion adjacent to the gastric cardia. Contrast-enhanced computed tomography and magnetic resonance imaging demonstrated a well-circumscribed, non-enhancing cystic mass, but the exact origin and nature of the lesion remained uncertain. Endoscopic ultrasound showed a 4.5 \u00d7 5.0 cm homogeneous hypoechoic lesion arising from the muscularis propria layer of the gastric cardia. Endoscopic ultrasound-guided fine-needle aspiration yielded dark-brown, turbid cyst fluid, and cyst-fluid analysis showed a neutrophil-predominant, exudative profile with markedly elevated tumor-associated markers, including CEA, CA19-9, CA125, and CYFRA 21-1. Microbiological smear and culture examinations for bacteria, fungi, and mycobacteria were negative. Given the patient's symptoms, lesion size, uncertain diagnosis, abnormal cyst-fluid profile, and inability to exclude a cystic neoplasm preoperatively, laparoscopic cyst excision with gastric wall repair was performed. Histopathological examination confirmed the diagnosis of a bronchogenic cyst, characterized by pseudostratified ciliated columnar epithelium and smooth muscle within the cyst wall. The patient recovered uneventfully, and no recurrence was observed during 1 year of follow-up. This case highlights the diagnostic challenges of gastric bronchogenic cysts and the complementary role of endoscopic ultrasound in localizing and characterizing subepithelial cystic lesions. Elevated cyst-fluid tumor markers should be interpreted cautiously and should not be regarded as evidence of malignancy in isolation, as their diagnostic and prognostic significance in gastric bronchogenic cysts remains uncertain.<\/jats:p>","DOI":"10.3389\/fmed.2026.1849801","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:28:54Z","timestamp":1781843334000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A rare case of gastric cardia bronchogenic cyst: diagnostic challenges and EUS findings with elevated cyst-fluid tumor markers"],"prefix":"10.3389","volume":"13","author":[{"given":"Jun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, 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