{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:01:33Z","timestamp":1790146893281,"version":"4.0.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) is a dynamic, multisystem disorder. Blood purification (BP) is increasingly utilized in severe or hypertriglyceridemia-associated AP, yet the overall patterns and cross-dimensional heterogeneity of post-BP laboratory shifts remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map the patterns, magnitudes, cross-system correlations, and patient-level heterogeneity of paired laboratory parameter changes observed before and after BP in AP patients using real-world data, strictly without inferring causal efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study analyzed 141 consecutive AP patients receiving BP (hemoperfusion, plasma exchange, or combined). Paired laboratory indicators across seven biological domains were compared. An exploratory multisystem laboratory change score (0\u223c6) was constructed to evaluate directional consistency. Rule-based stratification was applied to examine change patterns alongside change-magnitude ranking and subgroup analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most laboratory indicators exhibited post-treatment reductions. The largest relative median decreases occurred in IL-6 (\u221286.79%), serum amylase (\u221286.67%), and triglycerides (\u221286.23%). The mean multisystem change score was 4.24\u2009\u00b1\u20091.34; concurrent directional shifts occurred across \u22653 domains in 87.94% of patients and \u22654 domains in 70.92%. Exploratory stratification identified subgroups exhibiting greater, intermediate, or smaller multidimensional shifts. Correlation analysis demonstrated strong intra-domain synchrony between renal parameters (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.726), but weak or non-significant cross-domain correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with AP showed marked, heterogeneous pre- to post-BP multidimensional laboratory shifts. Lacking a contemporaneous control group, these observational changes cannot be causally attributed to BP and reflect the combined influence of natural disease evolution, fluid resuscitation, and concurrent supportive care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1850265","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:18:12Z","timestamp":1790144292000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem laboratory changes before and after blood purification in acute pancreatitis: a real-world descriptive analysis of 141 cases"],"prefix":"10.3389","volume":"13","author":[{"given":"Guoying","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Nephrology, The People's Hospital of The Qiandongnan Miao and Dong Autonomous Prefecture","place":["Kaili, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cendan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The People's Hospital of The Qiandongnan Miao and Dong Autonomous Prefecture","place":["Kaili, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The People's Hospital of The Qiandongnan Miao and Dong Autonomous Prefecture","place":["Kaili, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The People's Hospital of The Qiandongnan Miao and Dong Autonomous Prefecture","place":["Kaili, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The People's Hospital of The Qiandongnan Miao and Dong Autonomous Prefecture","place":["Kaili, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The People's Hospital of The Qiandongnan Miao and Dong Autonomous Prefecture","place":["Kaili, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"IAP\/APA evidence-based guidelines for the management of acute 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