{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:50:48Z","timestamp":1782449448357,"version":"3.54.5"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Primary cutaneous diffuse large B-cell lymphoma (PC-DLBCL) is a rare subtype of non-Hodgkin lymphoma with nonspecific cutaneous manifestations, leading to frequent misdiagnosis. This case describes an elderly patient with severe ulcerative skin lesions who was misdiagnosed repeatedly and required multidisciplinary orthopedic\u2013hematologic management, thus providing valuable evidence for clinical practice. An 85-year-old male presented with progressive erythematous papules, ulcers, and subcutaneous nodules on the right forearm, chest, back, and left upper arm. Pathology and immunohistochemistry confirmed primary cutaneous diffuse large B-cell lymphoma. He underwent orthopedic debridement, autologous skin grafting, and 4 cycles of R-miniCHOP immunochemotherapy. Skin lesions resolved completely without recurrence, and 7-month follow-up showed favorable recovery. The key take-away is that PC-DLBCL is often misdiagnosed; early pathological biopsy and multidisciplinary collaboration between orthopedics and hematology-oncology are essential for accurate diagnosis and effective treatment to improve prognosis in elderly patients.<\/jats:p>","DOI":"10.3389\/fmed.2026.1852379","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:32:49Z","timestamp":1782448369000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Misdiagnosis analysis and multidisciplinary collaborative treatment of primary cutaneous diffuse large B-cell lymphoma: case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Hongjuan","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine, The 988th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, The 988th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The 988th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, The 988th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The 988th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fmicb.2022.1085086","article-title":"Analysis of the epidemic status of malignant tumors in China in 2022","volume":"46","author":"Zheng","year":"2022","journal-title":"Chin J Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3390\/cancers17071202","article-title":"Unveiling primary cutaneous B-cell lymphomas: new insights into diagnosis and treatment 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