{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:54:11Z","timestamp":1791176051623,"version":"4.1.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intrarenal cyst infection in polycystic kidney disease (PKD) is hard to confirm and harder to treat during pregnancy, when lipid-soluble antibiotics are generally avoided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A pregnant woman at approximately 10 weeks\u2019 gestation presented with recurrent fever and flank pain for over one month, with acute exacerbation one day prior to admission. Laboratory tests revealed progressively elevated C-reactive protein (CRP) levels despite repeatedly negative cultures. Serial ultrasound showed a right upper-pole renal cyst that evolved to exhibit internal septations and debris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Treatment and outcome<\/jats:title>\n                    <jats:p>Cyst aspiration was avoided; meropenem 1\u2005g every 8\u2005h was initiated on admission and converted to prolonged infusion (1\u2005g infused over more than 3\u2005h) on Day 4, followed by step-down oral amoxicillin\u2013clavulanate, for a total antimicrobial course of 32 days. Fever resolved and CRP normalized; pregnancy continued uneventfully.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a pregnant patient with suspected PKD cyst infection, prolonged-infusion meropenem was followed by clinical improvement. The favorable response observed supports further evaluation of this therapeutic strategy, despite the absence of microbiological confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1856558","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:36:39Z","timestamp":1791174999000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged infusion of meropenem for suspected intracystic infection in polycystic kidney disease during pregnancy: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Bingqing","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wenling Maternal and Child Health Hospital","place":["Wenling, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danjia","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wenling Maternal and Child Health Hospital","place":["Wenling, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangqi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wenling Maternal and Child Health Hospital","place":["Wenling, Zhejiang, China"]},{"name":"Ultrasound Room, Wenling Maternal and Child Health Hospital, Wenling, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianying","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wenling Maternal and Child Health Hospital","place":["Wenling, Zhejiang, China"]},{"name":"Department of Pharmacy, Wenling Maternal and Child Health Hospital, Wenling, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.2215\/CJN.01870309","article-title":"Cyst infections in patients with autosomal dominant polycystic kidney disease","volume":"4","author":"Sall\u00e9e","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/ndt\/gfv452","article-title":"Management of renal cyst infection in patients with autosomal dominant polycystic kidney disease: a systematic review","volume":"32","author":"Lantinga","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"B3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/IJWH.S204997","article-title":"Management of autosomal dominant polycystic kidney disease (ADPKD) during pregnancy: risks and 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