{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:28:54Z","timestamp":1787131734577,"version":"build-2736575974"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Person-centred prescription (PCP) is a medication revision based on patients\u2019 frailty status and diagnostic- and drug-centred criteria. This pragmatic trial aims to implement and evaluate a multidimensional PCP intervention to improve pharmacological treatment adequacy in older adults admitted to an intermediate care hospital (ICH), following a mixed-method approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Description<\/jats:title>\n                    <jats:p>The \u201cApplying a Multidisciplinary Intervention for Drug Adequacy-ICH\u201d (AMIDA-ICH) study follows a hybrid design. Five hospital wards will enter the intervention phase following a stepped\u2013wedge randomized clinical trial design. Subjects belonging to the control phase will receive usual care; those belonging to the intervention phase will undergo a multidisciplinary PCP. We will evaluate the intervention\u2019s impact on reducing medications and improving treatment adequacy, patient-reported outcome measures, and health outcomes, such as adverse events, hospital admissions, and mortality. Finally, the qualitative part will involve professionals, patients, and carers with the aim of identifying barriers and enablers to implement the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study is designed to improve therapeutic adequacy and quality of care in older adults through a PCP approach. It focuses on outcomes like efficacy and safety, while also assessing the real-world applicability of the intervention through implementation outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/clinicaltrials.gov\/study\/NCT07015112<\/jats:ext-link>\n                      , NCT07015112.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1857969","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:10:13Z","timestamp":1787130613000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Applying a multidisciplinary intervention for drug adequacy in an intermediate care hospital (AMIDA-ICH): study protocol of a complex intervention trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Francesco","family":"Salis","sequence":"first","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"Department of Medical Sciences and Public Health, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Soler-Blanco","sequence":"additional","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"Parc Sanitari Pere Virgili","place":["Barcelona, Catalunya, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Molist-Brunet","sequence":"additional","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"Parc Sanitari Pere Virgili","place":["Barcelona, Catalunya, Spain"]},{"name":"Universitat de Vic-Universitat Central de Catalunya (UVic-UCC)","place":["Vic, Catalunya, Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Catalunya, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Gual-Tarrada","sequence":"additional","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Catalunya, Spain"]},{"name":"Vall d\u2019Hebr\u00f3n University Hospital","place":["Barcelona, Catalunya, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Ribera","sequence":"additional","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)","place":["Barcelona, Catalunya, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Geriatria, Accettazione Geriatrica e Centro di ricerca per l'invecchiamento, IRCCS INRCA","place":["Ancona, Italy"]},{"name":"Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche","place":["Ancona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Inzitari","sequence":"additional","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"Parc Sanitari Pere Virgili","place":["Barcelona, Catalunya, Spain"]},{"name":"Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC)","place":["Barcelona, Catalunya, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"de Andr\u00e9s-L\u00e1zaro","sequence":"additional","affiliation":[{"name":"RE-FiT Barcelona Research Group, Vall d\u2019Hebr\u00f3n Institute of Research (VHIR)","place":["Barcelona, Catalunya, Spain"]},{"name":"Parc Sanitari Pere Virgili","place":["Barcelona, Catalunya, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101537","DOI":"10.1016\/j.arr.2021.101537","article-title":"A gerophysiology perspective on healthy ageing","volume":"73","author":"Kemoun","year":"2022","journal-title":"Ageing Res 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