{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:47:43Z","timestamp":1782712063764,"version":"3.54.5"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several factors are associated with hypophosphatemia. There is a paucity of data regarding the effects of restrictive energy delivery and phosphate renal handling with hypophosphatemia in the critically ill patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a single-center observational study. Patients were included if they were admitted ventilated and their ICU stay was at least 48 h. Baseline characteristics were recorded upon admission; other variables were collected daily during the first five admission days: SOFA1 score, serum phosphate, energy delivery, phosphate delivery and fluid balance. A 6-h urine collection for phosphate and creatinine was performed daily. Creatinine clearance (CrCl\n                      <jats:sub>6hr<\/jats:sub>\n                      ), tubular reabsorption of phosphate (TRP), and tubular maximal reabsorption rate of phosphate adjusted to the glomerular filtration rate (TmP\/GFR) were calculated. Mortality follow up time was 90 days. A comparison was made between patients who developed hypophosphatemia (serum phosphate &amp;lt; 2.5 mg\/dl), and those who did not. Univariate and multivariate regressions for hypophosphatemia and for 90-day mortality were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred eighty-one patients were included in the analysis. One hundred and nine (60.22%) developed hypophosphatemia. They were younger, had lower APACHE2 score, and were admitted more frequently due to trauma. No association of energy delivery with hypophosphatemia was found. In a multivariate analysis only log of CrCl\n                      <jats:sub>6hr<\/jats:sub>\n                      and TmP\/GFR were associated with hypophosphatemia. Hypophosphatemia was associated with 90-d mortality in univariate analysis, but not in multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Creatinine clearance based on a 6-h urine collection and TmP\/GFR were associated with hypophosphatemia, whereas energy delivery was not. Age and APACHE2 were associated with 90-d mortality, but hypophosphatemia was not.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1858326","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:39:01Z","timestamp":1782711541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypophosphatemia\u2013factors associated with its development and 90-day mortality effect: a prospective observational study"],"prefix":"10.3389","volume":"13","author":[{"given":"Liran","family":"Statlender","sequence":"first","affiliation":[{"name":"Department of General Intensive Care, Rabin Medical Center, Beilinson Hospital","place":["Petah Tikva, Israel"]},{"name":"School of Medicine, Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzippy","family":"Shochat","sequence":"additional","affiliation":[{"name":"Statistical 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