{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:08Z","timestamp":1785214808392,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Adenoid cystic carcinoma (ACC) is a malignant tumor characterized by the biphasic ductal and myoepithelial differentiation, a propensity for perineural invasion and distant metastasis, and relatively slow local progression. ACC primarily arises in the salivary glands, esophageal adenoid cystic carcinoma (EACC)often presents as a submucosal elevation with a smooth surface on endoscopy. This atypical morphological presentation often results in conventional mucosal biopsy sampling of only the normal squamous epithelium, leading to frequent preoperative misdiagnoses of EACC despite endoscopic detection. We report a 70-year-old male with an esophageal submucosal elevation detected via gastroscopy. After endoscopic ultrasound (EUS), the patient underwent endoscopic submucosal excision (ESE). Postoperative histopathology confirmed ACC with positive margins, after which patient received adjuvant radiotherapy and has remained clinically well on follow-up. This study aimed to explore the endoscopic features and diagnostic challenges of EACC and to discuss comprehensive treatment approach integrating endoscopy resection with radiotherapy.<\/jats:p>","DOI":"10.3389\/fmed.2026.1858717","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:26:42Z","timestamp":1785212802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A rare case of esophageal adenoid cystic carcinoma treated by endoscopic submucosal excavation combined with radiotherapy"],"prefix":"10.3389","volume":"13","author":[{"given":"Qunying","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Dongyang People\u2019s Hospital","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangHong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dongyang People\u2019s Hospital","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dongyang People\u2019s Hospital","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiJie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dongyang People\u2019s Hospital","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoDie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dongyang People\u2019s Hospital","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JianWen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dongyang People\u2019s Hospital","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1001\/archotol.1954.00710050171005","article-title":"Unusual neoplasms of the esophagus: review of literature and report of a case","volume":"59","author":"Gregg","year":"1954","journal-title":"AMA Arch Otolaryngol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s40792-015-0122-5","article-title":"A case of adenoid cystic carcinoma of the esophagus","volume":"1","author":"Sawada","year":"2015","journal-title":"Surg Case Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1007\/BF00309962","article-title":"Adenoid cystic carcinoma of the esophagus: report of a case and review of the Japanese literature","volume":"26","author":"Morisaki","year":"1996","journal-title":"Surg Today"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.5009\/gnl.2007.1.2.178","article-title":"Primary esophageal adenoid cystic carcinoma","volume":"1","author":"Na","year":"2007","journal-title":"Gut Liver"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/1746-1596-7-179","article-title":"Adenoid cystic carcinoma of the esophagus: report of two cases and review of the Chinese literature","volume":"7","author":"Guo","year":"2012","journal-title":"Diagn Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3892\/ol.2014.2153","article-title":"Adenoid cystic carcinoma of the cardia: report of a rare case and review of the Chinese literature","volume":"8","author":"Zhou","year":"2014","journal-title":"Oncol Lett"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2025.11558\/2025","article-title":"Endoscopic submucosal dissection and postoperative radiotherapy for the treatment of esophagus adenoid cystic carcinoma","author":"Hao","year":"2025","journal-title":"Rev Esp Enferm Dig"},{"key":"ref8","first-page":"1759","article-title":"A case of adenoid cystic carcinoma of the esophagus","volume":"35","author":"Murao","year":"1989","journal-title":"Gan No Rinsho"},{"key":"ref9","first-page":"180","article-title":"Two cases of adenoid cystic carcinoma of the esophagus","volume":"91","author":"Akiyama","year":"1994","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1722893","DOI":"10.3389\/fmed.2026.1722893","article-title":"Endoscopic resection of esophageal adenoid cystic carcinoma with submucosal origin and long-term follow-up: a case report","volume":"13","author":"Ma","year":"2026","journal-title":"Front Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/j.1742-1241.2005.00556.x","article-title":"Oesophageal adenoid cystic carcinoma and its management options","volume":"59","author":"Karaoglanoglu","year":"2005","journal-title":"Int J Clin Pract"},{"key":"ref12","first-page":"258","article-title":"Combination chemotherapy for a senile patient with adenoid cystic carcinoma of the esophagus: a case report","volume":"23","author":"Matsumoto","year":"1993","journal-title":"Jpn J Clin Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e16999","DOI":"10.1097\/MD.0000000000016999","article-title":"Adenoid cystic carcinoma of the gastroesophageal junction: a case report","volume":"98","author":"Shou","year":"2019","journal-title":"Medicine"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"E611","DOI":"10.1055\/a-2346-4863","article-title":"Endoscopic submucosal dissection for resection of giant adenoid cystic carcinoma of the esophagus","volume":"56","author":"Xia","year":"2024","journal-title":"Endoscopy"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"E49","DOI":"10.1055\/a-1889-5336","article-title":"Endoscopic submucosal dissection of squamous cell carcinoma accompanied by adenoid cystic carcinoma of the esophagus","volume":"55","author":"Aihua","year":"2023","journal-title":"Endoscopy"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"296","DOI":"10.14639\/0392-100X-N1729","article-title":"Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis","volume":"41","author":"Cant\u00f9","year":"2021","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.joms.2005.06.017","article-title":"Management of adenoid cystic carcinoma of minor salivary glands","volume":"64","author":"Perzin","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/1097-0142(197807)42:1<265::aid-cncr2820420141>3.0.co;2-z","article-title":"Adenoid cystic carcinomas arising in salivary glands: a correlation of histologic features and clinical course","volume":"42","author":"Gullane","year":"1978","journal-title":"Cancer"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"630","DOI":"10.12998\/wjcc.v12.i3.630","article-title":"Rare esophageal carcinoma-primary adenoid cystic carcinoma of the esophagus: a case report","volume":"12","author":"Geng","year":"2024","journal-title":"World J Clin Cases"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.ejca.2015.09.004","article-title":"Nomograms for predicting survival and recurrence in patients with adenoid cystic carcinoma. An international collaborative study","volume":"51","author":"Ganly","year":"2015","journal-title":"Eur J Cancer"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1858717\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:26:43Z","timestamp":1785212803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1858717\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":20,"alternative-id":["10.3389\/fmed.2026.1858717"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1858717","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"article-number":"1858717"}}